Childhood Exposure to Passive Smoking and Bone Health in Adulthood: The Cardiovascular Risk in Young Finns Study.

Autor:	Juonala M; Department of Medicine, University of Turku and Division of Medicine, Turku University Hospital, Turku, Finland.; Murdoch Childrens Research Institute, Parkville, Victoria, Australia., Pitkänen N; Research Center of Applied and Preventive Cardiovascular Medicine, University of Turku, Turku, Finland., Tolonen S; Department of Food and Nutrition, University of Helsinki, Helsinki, Finland., Laaksonen M; Department of Food and Nutrition, University of Helsinki, Helsinki, Finland., Sievänen H; UKK-institute, Tampere, Finland., Jokinen E; Department of Pediatric Cardiology, Hospital for Children and Adolescents, University of Helsinki, Helsinki, Finland., Laitinen T; Department of Clinical Physiology, University of Eastern Finland and Kuopio University Hospital, Kuopio, Finland., Sabin MA; Murdoch Childrens Research Institute, Parkville, Victoria, Australia.; Royal Children's Hospital, Parkville, Victoria, Australia., Hutri-Kähönen N; Department of Pediatrics, Tampere University and Tampere University Hospital, Tampere, Finland., Lehtimäki T; Department of Clinical Chemistry, Fimlab Laboratories and Faculty of Medicine and Health Technology, Finnish Cardiovascular Research Center- Tampere, Tampere University, Tampere, Finland., Taittonen L; Vaasa Central Hospital, Vaasa, Finland., Jula A; Department of Chronic Disease Prevention, National Institute for Health and Welfare, Turku, Finland., Loo BM; Department of Chronic Disease Prevention, National Institute for Health and Welfare, Turku, Finland.; Joint Clinical Biochemistry Laboratory of University of Turku and Turku University Hospital, Turku, Finland., Impivaara O; Department of Chronic Disease Prevention, National Institute for Health and Welfare, Turku, Finland., Kähönen M; Department of Clinical Physiology, Tampere University Hospital and Tampere University, Tampere, Finland., Magnussen CG; Research Center of Applied and Preventive Cardiovascular Medicine, University of Turku, Turku, Finland.; Menzies Institute for Medical Research, University of Tasmania, Hobart, Tasmania, Australia., Viikari JSA; Department of Medicine, University of Turku and Division of Medicine, Turku University Hospital, Turku, Finland., Raitakari OT; Research Center of Applied and Preventive Cardiovascular Medicine, University of Turku, Turku, Finland.; Department of Clinical Physiology and Nuclear Medicine, Turku University Hospital, Turku, Finland.
Jazyk:	angličtina
Zdroj:	The Journal of clinical endocrinology and metabolism [J Clin Endocrinol Metab] 2019 Jun 01; Vol. 104 (6), pp. 2403-2411.
DOI:	10.1210/jc.2018-02501
Abstrakt:	Context: Passive smoke exposure has been linked to the risk of osteoporosis in adults. Objective: We examined the independent effects of childhood passive smoke exposure on adult bone health. Design/setting: Longitudinal, the Cardiovascular Risk in Young Finns Study. Participants: The study cohort included 1422 individuals followed for 28 years since baseline in 1980 (age 3 to 18 years). Exposure to passive smoking was determined in childhood. In adulthood, peripheral bone traits were assessed with peripheral quantitative CT (pQCT) at the tibia and radius, and calcaneal mineral density was estimated with quantitative ultrasound. Fracture data were gathered by questionnaires. Results: Parental smoking in childhood was associated with lower pQCT-derived bone sum index in adulthood (β± SE, -0.064 ± 0.023 per smoking parent; P = 0.004) in multivariate models adjusted for age, sex, active smoking, body mass index, serum 25-OH vitamin D concentration, physical activity, and parental socioeconomic position. Similarly, parental smoking was associated with lower heel ultrasound estimated bone mineral density in adulthood (β± SE, -0.097 ± 0.041 per smoking parent; P = 0.02). Parental smoking was also associated with the incidence of low-energy fractures (OR, 1.28; 95% CI, 1.01 to 1.62). Individuals with elevated cotinine levels (3 to 20 ng/mL) in childhood had lower bone sum index with pQCT (β± SE, -0.206 ± 0.057; P = 0.0003). Children whose parents smoked and had high cotinine levels (3 to 20 ng/mL) had significantly lower pQCT-derived bone sum index compared with those with smoking parents but had low cotinine levels (<3 ng/mL) (β± SE, -0.192 ± 0.072; P = 0.008). Conclusions and Relevance: Children of parents who smoke have evidence of impaired bone health in adulthood. (Copyright © 2019 Endocrine Society.)
Databáze:	MEDLINE
Externí odkaz:	Zobrazit plný text záznamu