Methotrexate-associated Lymphoproliferative Disorder: A Rare Differential Diagnosis of Wheezes.

Autor: Ujino M; Division of Respiratory Medicine and Allergology, Department of Medicine, Teikyo University School of Medicine, Japan., Miyoshi S; Division of Respiratory Medicine and Allergology, Department of Medicine, Teikyo University School of Medicine, Japan., Sugimoto N; Division of Respiratory Medicine and Allergology, Department of Medicine, Teikyo University School of Medicine, Japan., Arai H; Division of Respiratory Medicine and Allergology, Department of Medicine, Teikyo University School of Medicine, Japan., Ota Y; Department of Pathology, Teikyo University School of Medicine, Japan.; Department of Pathology, Teikyo University Hospital, Japan., Sasajima Y; Department of Pathology, Teikyo University School of Medicine, Japan.; Department of Pathology, Teikyo University Hospital, Japan., Kawamura M; Department of Surgery, Teikyo University School of Medicine, Japan., Nagase H; Division of Respiratory Medicine and Allergology, Department of Medicine, Teikyo University School of Medicine, Japan., Yamaguchi M; Division of Respiratory Medicine and Allergology, Department of Medicine, Teikyo University School of Medicine, Japan., Ohta K; Division of Respiratory Medicine and Allergology, Department of Medicine, Teikyo University School of Medicine, Japan.; JATA Fukujuji Hospital, Japan.
Jazyk: angličtina
Zdroj: Internal medicine (Tokyo, Japan) [Intern Med] 2019 Jun 15; Vol. 58 (12), pp. 1759-1764. Date of Electronic Publication: 2019 Feb 01.
DOI: 10.2169/internalmedicine.2080-18
Abstrakt: A 70-year-old woman was admitted for the evaluation of wheezes and a nodular lesion in the left lung field. She had been diagnosed with rheumatoid arthritis at 45 years of age and was continuously treated with methotrexate (MTX) at 8 mg/week. Bronchoscopic aspiration histology of a hilar lymph node suggested a lymphoproliferative disorder (LPD). After discontinuation of MTX, the lung nodule and wheezes disappeared. Although wheezes are not a usual manifestation of LPD, her clinical course clearly demonstrated an obvious relationship between LPD-induced airway narrowing and wheezes.
Databáze: MEDLINE
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