Non-classical circulating monocytes in severe obesity and obesity with uncontrolled diabetes: A comparison with tuberculosis and healthy individuals.

Autor: Resende DP; Laboratório de Imunopatologia das Doenças Infecciosas, Instituto de Patologia Tropical e Saúde Pública, Universidade Federal de Goiás, Rua 235, Setor Universitário, Goiânia, Goiás, CEP 74605050 Brazil., da Costa AC; Laboratório de Imunopatologia das Doenças Infecciosas, Instituto de Patologia Tropical e Saúde Pública, Universidade Federal de Goiás, Rua 235, Setor Universitário, Goiânia, Goiás, CEP 74605050 Brazil., de Souza Rosa LP; Hospital das Clínicas- Programa de Pós-Graduação em Ciências da Saúde, Faculdade de Medicina- UFG, Goiânia, GO, Brazil; Primeira avenida, Setor Universitário, Goiânia, Goiás, CEP 75605020 Brazil., Rodrigues AP; Hospital das Clínicas- Programa de Pós-Graduação em Ciências da Saúde, Faculdade de Medicina- UFG, Goiânia, GO, Brazil; Primeira avenida, Setor Universitário, Goiânia, Goiás, CEP 75605020 Brazil., Santos ASEA; Hospital das Clínicas- Programa de Pós-Graduação em Ciências da Saúde, Faculdade de Medicina- UFG, Goiânia, GO, Brazil; Primeira avenida, Setor Universitário, Goiânia, Goiás, CEP 75605020 Brazil., Cardoso CK; Hospital das Clínicas- Programa de Pós-Graduação em Ciências da Saúde, Faculdade de Medicina- UFG, Goiânia, GO, Brazil; Primeira avenida, Setor Universitário, Goiânia, Goiás, CEP 75605020 Brazil., Sousa JD; Universidade Norte do Paraná, Avenida Paris, 675, Jardim Piza, CEP 86041-120, Londrina, Paraná, Brazil., Kipnis A; Laboratório de Bacteriologia Molecular, Instituto de Patologia Tropical e Saúde Pública, Universidade Federal de Goiás, Rua 235, Setor Universitário, Goiânia, Goiás, CEP 74605050 Brazil., Silveira EA; Hospital das Clínicas- Programa de Pós-Graduação em Ciências da Saúde, Faculdade de Medicina- UFG, Goiânia, GO, Brazil; Primeira avenida, Setor Universitário, Goiânia, Goiás, CEP 75605020 Brazil., Junqueira-Kipnis AP; Laboratório de Imunopatologia das Doenças Infecciosas, Instituto de Patologia Tropical e Saúde Pública, Universidade Federal de Goiás, Rua 235, Setor Universitário, Goiânia, Goiás, CEP 74605050 Brazil. Electronic address: ana_kipnis@ufg.br.
Jazyk: angličtina
Zdroj: Tuberculosis (Edinburgh, Scotland) [Tuberculosis (Edinb)] 2019 Jan; Vol. 114, pp. 30-41. Date of Electronic Publication: 2018 Nov 05.
DOI: 10.1016/j.tube.2018.11.003
Abstrakt: Severe obesity and diabetes lead to a significant decrease in quality of life. Although controversial, population-wide studies have implicated obesity in the development of tuberculosis (TB). Non-classical monocytes have been described in obesity and TB, whereas in diabetes they have been associated with poorer clinical outcomes. The present study focuses on the functional significance of several monocyte populations of obese, obesity-related diabetic (OBDM), non-obese/diabetic tuberculosis and non-obese healthy control patients. Monocytes were evaluated by measuring expression of CD86, CD206, TLR-2 and TLR-4 as well as production of IL-6, IL-12, and by using a mycobacterial growth inhibition assay for both Mycobacterium tuberculosis and M. abscessus subsp. massiliense. Non-classical monocytes from OBDM and non-obese TB patients exhibited similar activation profiles (CD86/CD206/TLR-2 and TLR-4 expressions). Only monocytes from TB patients had a higher positivity for IL-12 and IL-6, whereas adiponectin serum levels increased similarly between TB and OBDM patients. Monocytes from active TB patients and OBDM were more permissive to Mtb growth than obese individuals, but this susceptibility was not observed for M. abscessus subsp. massiliense. From these findings, we conclude that diabetes and tuberculosis had similarities in the population of circulating non-classical monocytes, improving our understanding of the association of these diseases.
(Copyright © 2018 Elsevier Ltd. All rights reserved.)
Databáze: MEDLINE
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