Update on Myogenic Sarcomas.
| Autor: | Agaram NP; Department of Pathology, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10065, USA. Electronic address: agaramn@mskcc.org. |
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| Jazyk: | angličtina |
| Zdroj: | Surgical pathology clinics [Surg Pathol Clin] 2019 Mar; Vol. 12 (1), pp. 51-62. Date of Electronic Publication: 2018 Dec 20. |
| DOI: | 10.1016/j.path.2018.10.003 |
| Abstrakt: | Myogenic sarcomas include soft tissue sarcomas that show skeletal muscle differentiation (rhabdomyosarcoma) and those with smooth muscle differentiation (leiomyosarcoma). Rhabdomyosarcomas are more common in the pediatric age group and leiomyosarcomas occur more often in the adult population. Based on the clinico-pathologic features and genetic abnormalities identified, the rhabdomyosarcomas are classified into embryonal, alveolar, spindle cell/sclerosing, and pleomorphic subtypes. Each subtype shows distinctive morphology and has characteristic genetic abnormalities. In this update on myogenic sarcomas, each entity is discussed with special emphasis on recent updates in genetic findings and the diagnostic approach to these tumors. (Copyright © 2018 Elsevier Inc. All rights reserved.) |
| Databáze: | MEDLINE |
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