Comparative Assessment of Clinical Benefit Using the ESMO-Magnitude of Clinical Benefit Scale Version 1.1 and the ASCO Value Framework Net Health Benefit Score.

Autor:	Cherny NI; Shaare Zedek Medical Center, Jerusalem, Israel., de Vries EGE; University of Groningen, Groningen, the Netherlands., Dafni U; National and Kapodistrian University of Athens, Athens, Greece.; Frontier Science Foundation-Hellas, Hellas, Greece., Garrett-Mayer E; American Society of Clinical Oncology, Alexandria, VA., McKernin SE; American Society of Clinical Oncology, Alexandria, VA., Piccart M; Jules Bordet Institute Université Libre de Bruxelles, Brussels, Belgium., Latino NJ; European Organisation for Research and Treatment of Cancer, Brussels, Belgium., Douillard JY; European Society for Medical Oncology, Lugano, Switzerland., Schnipper LE; Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA., Somerfield MR; American Society of Clinical Oncology, Alexandria, VA., Bogaerts J; European Organisation for Research and Treatment of Cancer, Brussels, Belgium., Karlis D; Athens University of Economics and Business, Athens, Greece., Zygoura P; Frontier Science Foundation-Hellas, Hellas, Greece., Vervita K; Frontier Science Foundation-Hellas, Hellas, Greece., Pentheroudakis G; Ioannina University Hospital, Ioannina, Greece., Tabernero J; Vall d'Hebron University Hospital and Institute of Oncology, Barcelona, Spain., Zielinski C; Medical University Vienna, Vienna, Austria., Wollins DS; American Society of Clinical Oncology, Alexandria, VA., Schilsky RL; American Society of Clinical Oncology, Alexandria, VA.
Jazyk:	angličtina
Zdroj:	Journal of clinical oncology : official journal of the American Society of Clinical Oncology [J Clin Oncol] 2019 Feb 01; Vol. 37 (4), pp. 336-349. Date of Electronic Publication: 2018 Dec 17.
DOI:	10.1200/JCO.18.00729
Abstrakt:	Purpose: To better understand the European Society for Medical Oncology-Magnitude of Clinical Benefit Scale version 1.1 (ESMO-MCBS v1.1) and the ASCO Value Framework Net Health Benefit score version 2 (ASCO-NHB v2), ESMO and ASCO collaborated to evaluate the concordance between the frameworks when used to assess clinical benefit attributable to new therapies. Methods: The 102 randomized controlled trials in the noncurative setting already evaluated in the field testing of ESMO-MCBS v1.1 were scored using ASCO-NHB v2 by its developers. Measures of agreement between the frameworks were calculated and receiver operating characteristic curves used to define thresholds for the ASCO-NHB v2 corresponding to ESMO-MCBS v1.1 categories. Studies with discordant scoring were identified and evaluated to understand the reasons for discordance. Results: The correlation of the 102 pairs of scores for studies in the noncurative setting is estimated to be 0.68 (Spearman's rank correlation coefficient; overall survival, 0.71; progression-free survival, 0.67). Receiver operating characteristic curves identified thresholds for ASCO-NHB v2 for facilitating comparisons with ESMO-MCBS v1.1 categories. After applying pragmatic threshold scores of 40 or less (ASCO-NHB v2) and 2 or less (ESMO-MCBS v1.1) for low benefit and 45 or greater (ASCO-NHB v2) and 4 to 5 (ESMO-MCBS v1.1) for substantial benefit, 37 discordant studies were identified. Major factors that contributed to discordance were different approaches to evaluation of relative and absolute gain for overall survival and progression-free survival, crediting tail of the curve gains, and assessing toxicity. Conclusion: The agreement between the frameworks was higher than observed in other studies that sought to compare them. The factors that contributed to discordant scores suggest potential approaches to improve convergence between the scales.
Databáze:	MEDLINE
Externí odkaz:	Zobrazit plný text záznamu