| Autor: |
de Castro TF; Programa de Pós-Graduação em Ciências Fisiológicas Instituto de Ciências Biológicas, Universidade Federal do Rio Grande, Rio Grande, RS, Brazil., Varela Junior AS; Reprodução Animal Comparada- RAC, Instituto de Ciências Biológicas, Universidade Federal do Rio Grande, Rio Grande, RS, Brazil., Padilha FF; Programa de Pós-Graduação em Biotecnologia Industrial, Universidade Tiradentes, Aracaju, SE, Brazil., Droppa-Almeida D; Programa de Pós-Graduação em Biotecnologia Industrial, Universidade Tiradentes, Aracaju, SE, Brazil. danieladroppa@gmail.com., Saalfeld GQ; Programa de Pós-Graduação em Ciências Fisiológicas Instituto de Ciências Biológicas, Universidade Federal do Rio Grande, Rio Grande, RS, Brazil., Pires DM; Reprodução Animal - Faculdade de Veterinária, Universidade Federal de Pelotas, Pelotas, RS, Brazil., Pereira JR; Reprodução Animal Comparada- RAC, Instituto de Ciências Biológicas, Universidade Federal do Rio Grande, Rio Grande, RS, Brazil., Corcini CD; Reprodução Animal - Faculdade de Veterinária, Universidade Federal de Pelotas, Pelotas, RS, Brazil., Colares EP; Reprodução Animal Comparada- RAC, Instituto de Ciências Biológicas, Universidade Federal do Rio Grande, Rio Grande, RS, Brazil. |
| Abstrakt: |
Triphenyltin (TPT) is an organotin compound (OT), primarily used in agriculture and in the composition of antifouling paints for ships worldwide. Studies have showed its effects as an endocrine disrupter in several organisms by preventing enzymatic expression and causing reproductive toxicity. This study aimed to evaluate the effects of exposure to TPT, via breastfeeding, on reproductive physiology in the Calomys laucha species. The experimental design was compound of five groups, two controls and three with different doses of TPT. Moreover, females were exposed by gavage to the TPT for 20 days, from the 1st day postpartum to the 21st postnatal day (PND). Then, the pups were euthanized and the kinetics, organelles, and biochemistry of the sperm were evaluated. The results presented a reduction in total motility in the groups exposed to TPT. Regarding cellular organelles analysis, a loss in membrane integrity was evidenced; the functionality of mitochondria showed diminution followed by increased acrosome reaction. In conclusion, the TPT causes alteration of the reproductive parameters, decreasing the activity and sperm quality in individuals exposed in the breastfeeding phase. |
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