| Autor: |
McGill CM; Department of Chemistry, University of Alaska-Anchorage, Anchorage, AK 99508 USA., Brown TJ; Department of Medicine, Division of Hematology and Oncology, Penn State Hershey Cancer Institute, Penn State College of Medicine, Hershey, PA 17033 USA.; Department of Internal Medicine, The University of Texas Southwestern Medical Center, Dallas, TX 75390 USA., Fisher LN; Department of Medicine, Division of Hematology and Oncology, Penn State Hershey Cancer Institute, Penn State College of Medicine, Hershey, PA 17033 USA., Gustafson SJ; Department of Chemistry and Biochemistry, University of Alaska-Fairbanks, Fairbanks, AK 99775., Dunlap KL; Department of Chemistry and Biochemistry, University of Alaska-Fairbanks, Fairbanks, AK 99775., Beck AJ; Drug Discovery, Development, and Delivery Core, Penn State College of Medicine, Hershey, PA 17033 USA., Toran PT; Department of Molecular, Cellular and Biomedical Sciences, University of New Hampshire, Durham, NH 03824 USA., Claxton DF; Department of Medicine, Division of Hematology and Oncology, Penn State Hershey Cancer Institute, Penn State College of Medicine, Hershey, PA 17033 USA., Barth BM; Department of Medicine, Division of Hematology and Oncology, Penn State Hershey Cancer Institute, Penn State College of Medicine, Hershey, PA 17033 USA.; Department of Molecular, Cellular and Biomedical Sciences, University of New Hampshire, Durham, NH 03824 USA. |
| Abstrakt: |
Acute myeloid leukemia (AML) is an aggressive hematological malignancy with limited treatment options. Inflammation is often a contributing factor to the development and progression of AML, and related diseases, and can potentiate therapy failure. Previously, we had identified anti-inflammatory roles and anti-AML efficacy for blueberry extracts. The present study extended these observations to determine that the polyphenol quercetin inhibited neutral sphingomyelinase (N-SMase) activity and exerted anti-AML efficacy. Moreover, quercetin was shown to exert combinatorial anti-AML efficacy with nanoliposomal ceramide. Overall, this demonstrated that quercetin could block the pro-inflammatory actions of N-SMase and augment the efficacy of anti-AML therapeutics, including ceramide-based therapeutics. |
