Association between platelet distribution width and serum uric acid in Chinese population.

Autor: Liu X; Department of Nuclear Medicine, Tianjin Medical University General Hospital, Tianjin, People's Republic of China., Wang H; Department of Nuclear Medicine, Tianjin Medical University General Hospital, Tianjin, People's Republic of China., Huang C; Hull York Medical School, University of Hull, Hull, UK., Meng Z; Department of Nuclear Medicine, Tianjin Medical University General Hospital, Tianjin, People's Republic of China., Zhang W; Department of Cardiology, Tianjin Medical University General Hospital, Tianjin, People's Republic of China., Li Y; Department of Cardiology, Tianjin Medical University General Hospital, Tianjin, People's Republic of China., Yu X; Department of Cardiology, Tianjin Medical University General Hospital, Tianjin, People's Republic of China., Du X; Department of Cardiology, Tianjin Medical University General Hospital, Tianjin, People's Republic of China., Liu M; Department of Endocrinology and Metabolism, Tianjin Medical University General Hospital, Tianjin, People's Republic of China., Sun J; Department of Health Management, Tianjin Medical University General Hospital, Tianjin, People's Republic of China., Zhang Q; Department of Health Management, Tianjin Medical University General Hospital, Tianjin, People's Republic of China., Gao Y; Department of Health Management, Tianjin Medical University General Hospital, Tianjin, People's Republic of China., Song K; Department of Health Management, Tianjin Medical University General Hospital, Tianjin, People's Republic of China., Wang X; Department of Health Management, Tianjin Medical University General Hospital, Tianjin, People's Republic of China., Zhao L; Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Tianjin Medical University, Tianjin, People's Republic of China., Fan Y; Tianjin Key Laboratory of Lung Cancer Metastasis and Tumor Microenvironment, Tianjin Lung Cancer Institute, Tianjin Medical University General Hospital, Tianjin, People's Republic of China.
Jazyk: angličtina
Zdroj: BioFactors (Oxford, England) [Biofactors] 2019 May; Vol. 45 (3), pp. 326-334. Date of Electronic Publication: 2019 Jan 30.
DOI: 10.1002/biof.1491
Abstrakt: Platelet distribution width (PDW) is a simple and inexpensive parameter, which could predict activation of coagulation efficiently. And it has been confirmed to have a significant role in many diseases. We aimed to explore the association between PDW and hyperuricemia in a large Chinese cohort. This cross-sectional study recruited 61,091 ostensible healthy participants (29,259 males and 31,832 females) after implementing exclusion criteria. Clinical data of the enrolled population included anthropometric measurements and serum parameters. Database was sorted by gender, and the association between PDW and hyperuricemia was analyzed after dividing PDW into quartiles. Crude and adjusted odds ratios of PDW for hyperuricemia with 95% confidence intervals were analyzed using binary logistic regression models. We found no significant difference in PDW values between the genders. Males showed significantly higher incidence of hyperuricemia than females. From binary logistic regression models, significant hyperuricemia risks only were demonstrated in PDW quartiles 2 and 3 in males (P < 0.05). This study displayed close association between PDW and hyperuricemia as a risk factor. It is meaningful to use PDW as a clinical risk predictor for hyperuricemia in males. © 2019 BioFactors, 45(3):326-334, 2019.
(© 2019 International Union of Biochemistry and Molecular Biology.)
Databáze: MEDLINE
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