| Autor: |
Ukolov AI, Kessenikh ED, Radilov AS, Goncharov NV |
| Jazyk: |
ruština |
| Zdroj: |
Zhurnal evoliutsionnoi biokhimii i fiziologii [Zh Evol Biokhim Fiziol] 2017 Jan; Vol. 53 (1), pp. 23-32. |
| Abstrakt: |
The metabolic profile of plasma of white non-linear rats was investigated under normal conditions and after chronic inhalational exposure to low doses of aliphatic hydrocarbons with the number of carbon atoms from 6 to 10. Metabolic profile was determined with combination of gas chromatography-mass spectrometry and high performance, high resolution liquid chromatography-mass spectrometry with subsequent use of chemometrical methods for data treatment and presentation. It was shown that continuous 90-day exposure to a mixture of C₆-C₁₀ saturated hydrocarbons at concentration of 160 ± 20.5 mg/m³ results in various impairments of metabolic processes in liver and kidneys. Exposure to hydrocarbons at doses of 31.4 ± 5.6 mg/m³ and 5.2 ± 1.8 mg/m³ evoked significantly smaller changes. Novel metabolic markers of the toxic effect of low concentrations of C₆-C₁₀ aliphatic hydrocarbons were revealed. The ratio of concentrations of pyrophosphoric and oxalic acids in rat blood plasma was found to be the most sensitive marker called <>. A hypothesis is put forward about the redox balance violation as the leading pathogenetic mechanism of neuropathies and concomitant pathologies associated with hydrocarbon chronic intoxication. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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