N-Acyl Homoserine Lactone Derived Tetramic Acids Impair Photosynthesis in Phaeodactylum tricornutum.

Autor:	Stock F; Protistology and Aquatic Ecology, Department of Biology , Ghent University , Krijgslaan 281/S8 , B-9000 Ghent , Belgium., Syrpas M; SynBioC, Department of Green Chemistry and Technology , Ghent University , Coupure Links 653 , B-9000 Ghent , Belgium., Graff van Creveld S; Department of Plant and Environmental Sciences, Faculty of Biochemistry , Weizmann Institute of Science , Il-76100 Rehovot , Israel., Backx S; SynBioC, Department of Green Chemistry and Technology , Ghent University , Coupure Links 653 , B-9000 Ghent , Belgium., Blommaert L; Protistology and Aquatic Ecology, Department of Biology , Ghent University , Krijgslaan 281/S8 , B-9000 Ghent , Belgium.; Institut de Biologie Physico-Chimique (IBPC), UMR 7141, Centre National de la Recherche Scientifique (CNRS) , Sorbonne Université , 13 Rue Pierre et Marie Curie , F-75005 Paris , France., Dow L; Plant Ecophysiology, Department of Biology , University of Konstanz , D-78457 Konstanz , Germany., Stock W; Protistology and Aquatic Ecology, Department of Biology , Ghent University , Krijgslaan 281/S8 , B-9000 Ghent , Belgium., Ruysbergh E; SynBioC, Department of Green Chemistry and Technology , Ghent University , Coupure Links 653 , B-9000 Ghent , Belgium., Lepetit B; Plant Ecophysiology, Department of Biology , University of Konstanz , D-78457 Konstanz , Germany., Bailleul B; Institut de Biologie Physico-Chimique (IBPC), UMR 7141, Centre National de la Recherche Scientifique (CNRS) , Sorbonne Université , 13 Rue Pierre et Marie Curie , F-75005 Paris , France., Sabbe K; Protistology and Aquatic Ecology, Department of Biology , Ghent University , Krijgslaan 281/S8 , B-9000 Ghent , Belgium., De Kimpe N; SynBioC, Department of Green Chemistry and Technology , Ghent University , Coupure Links 653 , B-9000 Ghent , Belgium., Willems A; Laboratory of Microbiology, Department of Biochemistry and Microbiology , Ghent University , B-9000 Ghent , Belgium., Kroth PG; Plant Ecophysiology, Department of Biology , University of Konstanz , D-78457 Konstanz , Germany., Vardi A; Department of Plant and Environmental Sciences, Faculty of Biochemistry , Weizmann Institute of Science , Il-76100 Rehovot , Israel., Vyverman W; Protistology and Aquatic Ecology, Department of Biology , Ghent University , Krijgslaan 281/S8 , B-9000 Ghent , Belgium., Mangelinckx S; SynBioC, Department of Green Chemistry and Technology , Ghent University , Coupure Links 653 , B-9000 Ghent , Belgium.
Jazyk:	angličtina
Zdroj:	ACS chemical biology [ACS Chem Biol] 2019 Feb 15; Vol. 14 (2), pp. 198-203. Date of Electronic Publication: 2019 Feb 06.
DOI:	10.1021/acschembio.8b01101
Abstrakt:	Marine bacteria contribute substantially to nutrient cycling in the oceans and can engage in close interactions with microalgae. Many microalgae harbor characteristic satellite bacteria, many of which participate in N-acyl homoserine lactone (AHL) mediated quorum sensing. In the diffusion-controlled phycosphere, AHLs can reach high local concentrations, with some of them transforming into tetramic acids, compounds with a broad bioactivity. We tested a representative AHL, N-(3-oxododecanoyl) homoserine lactone, and its tetramic acid rearrangement product on the diatom Phaeodactylum tricornutum. While cell growth and photosynthetic efficiency of photosystem II were barely affected by the AHL, exposure to its tetramic acid rearrangement product had a negative effect on photosynthetic efficiency and led to growth inhibition and cell death in the long term, with a minimum inhibitory concentration between 20 and 50 μΜ. These results strengthen the view that AHLs may play an important role in shaping the outcome of microalgae-bacteria interactions.
Databáze:	MEDLINE
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