Prevention of schizophrenia deficits via non-invasive adolescent frontal cortex stimulation in rats.

Autor: Hadar R; Department of Psychiatry and Psychotherapy, Charité University Medicine Berlin, Campus Mitte, Berlin, Germany.; Department of Psychiatry and Psychotherapy, Medical Faculty Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany., Winter R; Department of Psychiatry and Psychotherapy, Medical Faculty Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany., Edemann-Callesen H; Department of Psychiatry and Psychotherapy, Charité University Medicine Berlin, Campus Mitte, Berlin, Germany.; Department of Psychiatry and Psychotherapy, Medical Faculty Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany.; International Graduate Program Medical Neurosciences, Charité Universitätsmedizin Berlin, Berlin, Germany., Wieske F; Department of Psychiatry and Psychotherapy, Charité University Medicine Berlin, Campus Mitte, Berlin, Germany., Habelt B; Department of Psychiatry and Psychotherapy, Charité University Medicine Berlin, Campus Mitte, Berlin, Germany.; Department of Psychiatry and Psychotherapy, Medical Faculty Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany., Khadka N; Department of Biomedical Engineering, The City College of New York, CUNY, New York, NY, 10031, USA., Felgel-Farnholz V; Department of Psychiatry and Psychotherapy, Medical Faculty Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany., Barroeta-Hlusicka E; Department of Psychiatry and Psychotherapy, Charité University Medicine Berlin, Campus Mitte, Berlin, Germany.; Department of Psychiatry and Psychotherapy, Medical Faculty Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany., Reis J; Department of Neurology, University Medical Center, Albert Ludwigs University Freiburg, Freiburg, Germany., Tatarau CA; Department of Psychiatry and Psychotherapy, Charité University Medicine Berlin, Campus Mitte, Berlin, Germany., Funke K; Department of Neurophysiology, Medical School of the Ruhr-Universität Bochum, Bochum, Germany., Fritsch B; Department of Neurology, University Medical Center, Albert Ludwigs University Freiburg, Freiburg, Germany., Bernhardt N; Department of Psychiatry and Psychotherapy, Medical Faculty Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany., Bikson M; Department of Biomedical Engineering, The City College of New York, CUNY, New York, NY, 10031, USA., Nitsche MA; Department Psychology and Neurosciences, Leibniz Research Centre for Working Environment and Human Factors at TU Dortmund, Dortmund, Germany.; Department Neurology, University Hospital Bergmannsheil, Ruhr-Universität Bochum, Bochum, Germany., Winter C; Department of Psychiatry and Psychotherapy, Charité University Medicine Berlin, Campus Mitte, Berlin, Germany. christine.winter@charite.de.; Department of Psychiatry and Psychotherapy, Medical Faculty Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany. christine.winter@charite.de.
Jazyk: angličtina
Zdroj: Molecular psychiatry [Mol Psychiatry] 2020 Apr; Vol. 25 (4), pp. 896-905. Date of Electronic Publication: 2019 Jan 28.
DOI: 10.1038/s41380-019-0356-x
Abstrakt: Schizophrenia is a severe neurodevelopmental psychiatric affliction manifested behaviorally at late adolescence/early adulthood. Current treatments comprise antipsychotics which act solely symptomatic, are limited in their effectiveness and often associated with side-effects. We here report that application of non-invasive transcranial direct current stimulation (tDCS) during adolescence, prior to schizophrenia-relevant behavioral manifestation, prevents the development of positive symptoms and related neurobiological alterations in the maternal immune stimulation (MIS) model of schizophrenia.
Databáze: MEDLINE
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