| Autor: |
Escribano-Ferrer E; Department of Pharmacy and Pharmaceutical Technology and Physical-chemistry, Faculty of Pharmacy and Food Sciences, Institut of Nanoscience and Nanotechnology (IN2UB) , University of Barcelona , E-08028 Barcelona , Spain.; CIBER Physiopathology of Obesity and Nutrition (CIBER-OBN) , Instituto de Salud Carlos III , E-28029 Madrid , Spain., Queralt Regué J; Department of Biochemistry and Physiology, Faculty of Pharmacy and Food Sciences , University of Barcelona , E-08028 Barcelona , Spain., Garcia-Sala X; Department of Pharmacy and Pharmaceutical Technology and Physical-chemistry, Faculty of Pharmacy and Food Sciences, Institut of Nanoscience and Nanotechnology (IN2UB) , University of Barcelona , E-08028 Barcelona , Spain., Boix Montañés A; Department of Pharmacy and Pharmaceutical Technology and Physical-chemistry, Faculty of Pharmacy and Food Sciences, Institut of Nanoscience and Nanotechnology (IN2UB) , University of Barcelona , E-08028 Barcelona , Spain., Lamuela-Raventos RM; CIBER Physiopathology of Obesity and Nutrition (CIBER-OBN) , Instituto de Salud Carlos III , E-28029 Madrid , Spain.; Department of Nutrition, Food Sciences, and Gastronomy - INSA-UB, Faculty of Pharmacy and Food Sciences , University of Barcelona , E-08028 Barcelona , Spain. |
| Abstrakt: |
Flavonoids, found in almost all fruits and vegetables, belong to a class of plant secondary metabolites with a polyphenolic structure and have properties with health-improving potential. However, few experimental studies on the effects of flavonoids have been carried out in vivo after external application and using pure compounds. Aiming to fill this gap, in this study we tested the topical anti-inflammatory and antiallergic activity of three flavonoids of high purity, naringenin, naringenin chalcone, and quercetin, in mouse models. The topical anti-inflammatory effects were assessed against arachidonic acid- (AA) and tetradecanoylphorbol-13-acetate- (TPA) induced ear edema. The anti-inflammatory effect of naringenin against ear edema was noticeable at a 1% dose in the AA model and at half this dose in the TPA model. Quercetin (1.3%) did not exert any topical anti-inflammatory activity in the AA model, but its inhibitory effect in the TPA model was similar to that of naringenin (2%); in contrast, naringenin chalcone was more active against the AA-induced than TPA-induced inflammation. The flavonoid effect on IgE-mediated passive cutaneous anaphylaxis was also studied in mice, both intravenously and topically. Naringenin, naringenin chalcone, and quercetin all showed strong antiallergic activity after intravenous dosing (0.02%) and when applied topically (2%). The results of this study suggest that the flavonoids naringenin, naringenin chalcone, and quercetin may be useful alternatives for the topical treatment of inflammatory and allergic skin disorders. |
