Pancreatic ductal cell antigens are important in the development of invasive insulitis in Non-Obese Diabetic mice.

Autor: Jayasimhan A; Department of Immunology and Pathology, Monash University, Melbourne, Australia. Electronic address: abhirup.abhirupjayasimhan@monash.edu., Ellis DP; Department of Biochemistry and Molecular Biology, Monash University, Melbourne, Australia., Ziegler AI; Drug Discovery Biology, Monash Institute of Pharmaceutical Sciences, Monash University, Melbourne, Australia., Slattery RM; Department of Immunology and Pathology, Monash University, Melbourne, Australia.
Jazyk: angličtina
Zdroj: Journal of neuroimmunology [J Neuroimmunol] 2019 Feb 15; Vol. 327, pp. 1-9. Date of Electronic Publication: 2019 Jan 18.
DOI: 10.1016/j.jneuroim.2019.01.001
Abstrakt: Type 1 Diabetes (T1D) is an autoimmune disease in which insulin producing beta cells of the pancreas are selectively destroyed. Glial Fibrillary Acidic Protein (GFAP) expressed in peri-islet Schwann cells (pSCs) and in the ductal cells of the pancreas is one of the candidate autoantigens for T1D. Immune responses to GFAP expressing cell types precede the islet autoimmunity in Non-Obese Diabetic (NOD) mice. By removing MHC class I from GFAP expressing cell types, we tested the role of autoantigens presented by these cell types in the development of invasive insulitis. Our findings indicate that antigens expressed by pancreatic ductal cells are important in the development of invasive insulitis in NOD mice.
(Copyright © 2019 Elsevier B.V. All rights reserved.)
Databáze: MEDLINE
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