Increased PON lactonase activity in morbidly obese patients is associated with impaired lipid profile.

Autor:	Alaminos-Castillo MÁ; Unidad de Gestión Clínica de Laboratorio, Hospital Regional Universitario de Málaga, Málaga, Spain., Ho-Plagaro A; Unidad de Gestión Clínica de Aparato Digestivo, Hospital Universitario Virgen de la Victoria, Málaga, Spain.; Instituto de Investigación Biomédica de Málaga-IBIMA, Málaga, Spain.; Universidad de Málaga, Málaga, Spain., García-Serrano S; Instituto de Investigación Biomédica de Málaga-IBIMA, Málaga, Spain.; Unidad de Gestión Clínica de Endocrinología y Nutrición, Hospital Regional Universitario de Málaga, Málaga, Spain.; CIBER de Diabetes y Enfermedades Metabólicas Asociadas-CIBERDEM, Málaga, Spain., Santiago-Fernandez C; Unidad de Gestión Clínica de Aparato Digestivo, Hospital Universitario Virgen de la Victoria, Málaga, Spain.; Instituto de Investigación Biomédica de Málaga-IBIMA, Málaga, Spain.; Universidad de Málaga, Málaga, Spain., Rodríguez-Pacheco F; Unidad de Gestión Clínica de Aparato Digestivo, Hospital Universitario Virgen de la Victoria, Málaga, Spain.; Instituto de Investigación Biomédica de Málaga-IBIMA, Málaga, Spain., Garrido-Sanchez L; Instituto de Investigación Biomédica de Málaga-IBIMA, Málaga, Spain.; Unidad de Gestión Clínica de Endocrinología y Nutrición, Hospital Universitario Virgen de la Victoria, Málaga, Spain.; CIBER Fisiología de la Obesidad y Nutrición-CIBEROBN, Málaga, Spain., Rodriguez C; Unidad de Gestión Clínica de Aparato Digestivo, Hospital Universitario Virgen de la Victoria, Málaga, Spain.; Instituto de Investigación Biomédica de Málaga-IBIMA, Málaga, Spain., Valdes S; Instituto de Investigación Biomédica de Málaga-IBIMA, Málaga, Spain.; Unidad de Gestión Clínica de Endocrinología y Nutrición, Hospital Regional Universitario de Málaga, Málaga, Spain.; CIBER de Diabetes y Enfermedades Metabólicas Asociadas-CIBERDEM, Málaga, Spain., Gonzalo M; Unidad de Gestión Clínica de Endocrinología y Nutrición, Hospital Regional Universitario de Málaga, Málaga, Spain., Moreno-Ruiz FJ; Unidad de Gestión Clínica de Cirugía General, Digestiva y Trasplantes, Hospital Regional Universitario de Málaga, Málaga, Spain., Rodríguez-Cañete A; Unidad de Gestión Clínica de Cirugía General, Digestiva y Trasplantes, Hospital Regional Universitario de Málaga, Málaga, Spain., Montiel-Casado C; Unidad de Gestión Clínica de Cirugía General, Digestiva y Trasplantes, Hospital Regional Universitario de Málaga, Málaga, Spain., Garcia-Fuentes E; Unidad de Gestión Clínica de Aparato Digestivo, Hospital Universitario Virgen de la Victoria, Málaga, Spain.; Instituto de Investigación Biomédica de Málaga-IBIMA, Málaga, Spain.; CIBER Fisiología de la Obesidad y Nutrición-CIBEROBN, Málaga, Spain.
Jazyk:	angličtina
Zdroj:	International journal of clinical practice [Int J Clin Pract] 2019 Jun; Vol. 73 (6), pp. e13315. Date of Electronic Publication: 2019 Feb 14.
DOI:	10.1111/ijcp.13315
Abstrakt:	Aims: The paraoxonase-1 (PON1) enzyme could play an important role in the anti-oxidant capacity of high-density lipoprotein. However, there are no studies which analyse the evolution of the three activities of PON1 (PON arylesterase, PON paraoxonase and PON lactonase) after Roux-en-Y Gastric Bypass (RYGB) in morbidly obese subjects. We analysed the association of PON concentration and activities with the evolution of morbidly obese subjects who underwent RYGB, and its relationship with biochemical variables and different atherogenic indices. Methods: Twenty-seven non-obese and 82 morbidly obese subjects were studied before and 6 months after RYGB. Results: Before RYGB, morbidly obese subjects had a lower PON1 concentration (P < 0.05) and higher PON lactonase activity (P < 0.001) than non-obese subjects, with no differences in PON arylesterase and PON paraoxonase activities. After RYGB, PON1 concentration (P < 0.05) and PON lactonase activity (P < 0.001) decreased with regard to the presurgery state. PON lactonase activity correlated with the atherogenic index of plasma before (r = 0.19, P = 0.047) and after RYGB (r = 0.27, P = 0.035). In different multiple lineal regression analysis models, presurgery PON lactonase activity was associated with total cholesterol (β = 0.909, P < 0.001), LDL (β = 0.632, P = 0.006) and DBP (β = 0.230, P = 0.030) (R ² = 0.295), postsurgery PON lactonase activity was associated with esterified cholesterol (β = 0.362, P = 0.011) (R ² = 0.131), and the change (Δ) in PON lactonase activity after RYGB was associated with Δesterified cholesterol (β = 0.304, P = 0.030) (R ² = 0.093). Conclusions: PON lactonase activity is associated with the presence of morbid obesity and with an impaired lipid profile. All associations found could indicate the relationship between PON lactonase activity and the development of atherosclerosis. (© 2019 John Wiley & Sons Ltd.)
Databáze:	MEDLINE
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