Differential impacts on multiple forms of spatial and contextual memory in diazepam binding inhibitor knockout mice.

Autor: Ujjainwala AL; Department of Molecular and Integrative Physiology, University of Illinois at Urbana-Champaign, Urbana, Illinois., Courtney CD; Neuroscience Program, University of Illinois at Urbana-Champaign, Urbana, Illinois., Wojnowski NM; Department of Molecular and Integrative Physiology, University of Illinois at Urbana-Champaign, Urbana, Illinois., Rhodes JS; Neuroscience Program, University of Illinois at Urbana-Champaign, Urbana, Illinois.; Beckman Institute for Advanced Science and Technology, University of Illinois at Urbana-Champaign, Urbana, Illinois.; Department of Psychology, University of Illinois at Urbana-Champaign, Champaign, Illinois., Christian CA; Department of Molecular and Integrative Physiology, University of Illinois at Urbana-Champaign, Urbana, Illinois.; Neuroscience Program, University of Illinois at Urbana-Champaign, Urbana, Illinois.; Beckman Institute for Advanced Science and Technology, University of Illinois at Urbana-Champaign, Urbana, Illinois.
Jazyk: angličtina
Zdroj: Journal of neuroscience research [J Neurosci Res] 2019 Jun; Vol. 97 (6), pp. 683-697. Date of Electronic Publication: 2019 Jan 25.
DOI: 10.1002/jnr.24393
Abstrakt: Learning and memory are fundamental processes that are disrupted in many neurological disorders including Alzheimer's disease and epilepsy. The hippocampus plays an integral role in these functions, and modulation of synaptic transmission mediated by γ-aminobutyric acid (GABA) type-A receptors (GABA A Rs) impacts hippocampus-dependent learning and memory. The protein diazepam binding inhibitor (DBI) differentially modulates GABA A Rs in various brain regions, including hippocampus, and changes in DBI levels may be linked to altered learning and memory. The effects of genetic loss of DBI signaling on these processes, however, have not been determined. In these studies, we examined male and female constitutive DBI knockout mice and wild-type littermates to investigate the role of DBI signaling in modulating multiple forms of hippocampus-dependent spatial learning and memory. DBI knockout mice did not show impaired discrimination of objects in familiar and novel locations in an object location memory test, but did exhibit reduced time spent exploring the objects. Multiple parameters of Barnes maze performance, testing the capability to utilize spatial reference cues, were disrupted in DBI knockout mice. Furthermore, whereas most wild-type mice adopted a direct search strategy upon learning the location of the target hole, knockout mice showed higher rates of using an inefficient random strategy. In addition, DBI knockout mice displayed typical levels of contextual fear conditioning, but lacked a sex difference observed in wild-type mice. Together, these data suggest that DBI selectively influences certain forms of spatial learning and memory, indicating novel roles for DBI signaling in modulating hippocampus-dependent behavior in a task-specific manner.
(© 2019 Wiley Periodicals, Inc.)
Databáze: MEDLINE
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