Cardiovascular disease and survival in non-small cell lung cancer: a multicenter prospective assessment.

Autor: Herrero Rivera D; Department of Medical Oncology, University Hospital Virgen del Rocío, Seville, Spain., Nieto-Guerrero Gómez JM; Department of Radiation Oncology, University Hospital Virgen del Rocío, Manuel Siurot Avenue, s/n, 41013, Seville, Spain., Cacicedo Fernández de Bobadilla J; Department of Radiation Oncology, Cruces University Hospital, Barakaldo, Spain., Delgado D; Department of Radiation Oncology, University Hospital Virgen del Rocío, Manuel Siurot Avenue, s/n, 41013, Seville, Spain., Rivin Del Campo E; Department of Radiation Oncology, Tenon University Hospital, Paris, France., Praena-Fernández JM; Methodology Unit, University Hospital Virgen del Rocío, Seville, Spain., Bernabé Caro R; Department of Medical Oncology, University Hospital Virgen del Rocío, Seville, Spain., Ortiz Gordillo MJ; Department of Radiation Oncology, University Hospital Virgen del Rocío, Manuel Siurot Avenue, s/n, 41013, Seville, Spain.; Instituto de Biomedicina de Sevilla (IBIS/HUVR, CSIC/Universidad de Sevilla), Seville, Spain., Fernández Fernández MC; Department of Radiation Oncology, University Hospital Virgen del Rocío, Manuel Siurot Avenue, s/n, 41013, Seville, Spain., Lopez Guerra JL; Department of Radiation Oncology, University Hospital Virgen del Rocío, Manuel Siurot Avenue, s/n, 41013, Seville, Spain. chanodetriana@yahoo.es.; Instituto de Biomedicina de Sevilla (IBIS/HUVR, CSIC/Universidad de Sevilla), Seville, Spain. chanodetriana@yahoo.es.
Jazyk: angličtina
Zdroj: Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico [Clin Transl Oncol] 2019 Sep; Vol. 21 (9), pp. 1220-1230. Date of Electronic Publication: 2019 Jan 24.
DOI: 10.1007/s12094-019-02047-5
Abstrakt: Purpose: Chronic inflammation contributes to cancer development via multiple mechanisms. We hypothesized that cardiovascular diseases (CVD) are also an independent risk factor for survival in non-small cell lung cancer (NSCLC).
Materials and Methods: Prospective multicenter data from 345 consecutive NSCLC patients treated from January 2013 to January 2017 were assessed. Median follow-up for all patients was 13 months (range 3-60 months). There were 109 patients with baseline heart disease (HD 32%), 149 with arterial hypertension (43%), 85 with diabetes mellitus (25%), 129 with hyperlipidemia (37%) and 45 with venous thromboembolism events (VTE 13%). A total of 289 patients (84%) were treated with platinum-based chemotherapy (CT), 300 patients (87%) received thoracic radiation therapy (RT; median radiation dose: 60 Gy [range 12-70]); and 50 (15%) patients underwent surgery.
Results: Our cohort consisted of 305 men (88%) and 40 (12%) women, with a median age of 67 years (range 31-88 years). Seventy percent had a Karnofsky performance status (KPS) ≥ 80. Multivariate analyses showed a lower OS and higher risk of distant metastasis in patients with advanced stages (p = 0.05 and p < 0.001, respectively) and HD (HR 1.43, p = 0.019; and HR 1.49, p = 0.025, respectively). Additionally, patients with VTE had lower local control (HR 1.84, p = 0.025), disease-free survival (HR 1.64, p = 0.020) and distant metastasis-free survival (HR 1.73, p = 0.025).
Conclusions: HD and VTE are associated with a higher risk of mortality and distant metastasis in NSCLC patients. Chronic inflammation associated with CVDs could be an additional pathophysiologic factor in the development of distant metastasis.
Databáze: MEDLINE
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