Early sleep deprivation and attention-deficit/hyperactivity disorder.

Autor: Tso W; Department of Paediatrics and Adolescent Medicine, The University of Hong Kong, Queen Mary Hospital, 102 Pokfulam Road, Pokfulam, Hong Kong., Chan M; Department of Psychiatry, The University of Hong Kong, Queen Mary Hospital, 102 Pokfulam Road, Pokfulam, Hong Kong., Ho FK; Department of Paediatrics and Adolescent Medicine, The University of Hong Kong, Queen Mary Hospital, 102 Pokfulam Road, Pokfulam, Hong Kong., Rao N; Faculty of Education, The University of Hong Kong, Pokfulam, Hong Kong. nrao@hku.hk., Li AM; Department of Paediatrics, The Chinese University of Hong Kong, Prince of Wales Hospital, 30 Ngan Shing Street, Sha Tin, Hong Kong., Chan KL; Department of Applied Social Science, The Hong Kong Polytechnic University, Pokfulam, Hong Kong., Tiwari A; School of Nursing, The University of Hong Kong, Pokfulam, Hong Kong., Wong ICK; Department of Pharmacology and Pharmacy, The University of Hong Kong, Pokfulam, Hong Kong., Wing YK; Department of Psychiatry, The Chinese University of Hong Kong, Shatin Hospital, 33A Kung Kok Street, Ma On Shan, Hong Kong., Van Voorhees B; Department of Paediatrics, College of Medicine at Chicago, University of Illinois, Chicago, IL, USA., Li SL; Department of Paediatrics and Adolescent Medicine, The University of Hong Kong, Queen Mary Hospital, 102 Pokfulam Road, Pokfulam, Hong Kong., Goh WHS; Division of Medicine, KK Women's and Children's Hospital, 100 Bukit Timah Road, Kallang, Singapore., Ip P; Department of Paediatrics and Adolescent Medicine, The University of Hong Kong, Queen Mary Hospital, 102 Pokfulam Road, Pokfulam, Hong Kong. patricip@hku.hk.
Jazyk: angličtina
Zdroj: Pediatric research [Pediatr Res] 2019 Mar; Vol. 85 (4), pp. 449-455. Date of Electronic Publication: 2019 Jan 17.
DOI: 10.1038/s41390-019-0280-4
Abstrakt: Background: This study aims to study prospectively specific sleep patterns and risk of ADHD after adjusting for potential confounders such as obstructive sleep apnoea (OSA) and methylphenidate use.
Methods: A population-representative sample of 514 Chinese preschool children was recruited when in kindergarten (K3). Parents reported on their socioeconomic status and children's sleep duration. The cohort was reassessed 3 years later when the children were in Grade 3 (P3). Parents reported on children's sleep patterns and ADHD symptoms. Information on OSA diagnosis and methylphenidate use was retrieved from health records.
Results: Among the 514 parent-child dyads (mean [SD] age, 5.52 [0.33] years), 411 were reassessed (80.0% retention; 9.35 [0.33] years) at follow-up. There were no significant baseline differences between follow-up and drop-out groups. A gradient relationship was observed between probable ADHD in P3 and sleep duration in K3. The risk of probable ADHD was 15.5 per 100 for children with <8 h of sleep in K3, whereas it was 1.1 per 100 for children with 11-12 h of sleep in K3. The adjusted risk ratio was 14.19 (p = 0.02).
Conclusions: Sleep deprivation in early childhood is associated with higher risk of ADHD in middle childhood.
Databáze: MEDLINE
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