IgE-Mediated Sensitization to Galactose-α-1,3- Galactose (α-Gal) in Urticaria and Anaphylaxis in Spain: Geographical Variations and Risk Factors.

Autor:	Mateo Borrega MB; GAI Guadalajara, Department of Allergy, Hospital Universitario de Guadalajara, Guadalajara, Spain., Garcia B; Department of Allergy, Complejo Hospitalario de Navarra, Pamplona, Spain., Larramendi CH; Allergy Section, Hospital Marina Baixa, Villajoyosa, Spain., Azofra J; Department of Allergy, Hospital Universitario Central de Asturias, Oviedo, Spain., González Mancebo E; Department of Allergy, Hospital Universitario de Fuenlabrada, Madrid, Spain., Alvarado MI; Department of Allergy, Hospital Virgen del Puerto, Plasencia, Spain., Alonso Díaz de Durana MD; Department of Allergy, Hospital Universitario Fundación de Alcorcón, Madrid, Spain., Núñez Orjales R; Department of Allergy, Hospital Universitario Lucus Augusti, Lugo, Spain., Diéguez MC; Department of Allergy, Research Institute Hospital 12 de Octubre (i+12), Madrid, Spain., Guilarte M; Department of Allergy, Hospital Universitari de la Vall d'Hebron, Barcelona, Spain., Soriano Galarraga AM; Department of Allergy, Hospital de Basurto, Bilbao, Spain., Sosa G; Department of Allergy, Hospital La Zarzuela, Madrid, Spain., Ferrer A; Department of Allergy, Hospital Vega Baja, Orihuela, Spain., García Moral A; Department of Allergy, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain., Beristain AM; Department of Allergy, Hospital Universitario Central de Asturias, Oviedo, Spain., Bartra J; Allergy Unit, Pneumology Department, Hospital Clinic, Barcelona, Spain.
Jazyk:	angličtina
Zdroj:	Journal of investigational allergology & clinical immunology [J Investig Allergol Clin Immunol] 2019; Vol. 29 (6), pp. 436-443. Date of Electronic Publication: 2019 Jan 24.
DOI:	10.18176/jiaci.0373
Abstrakt:	Background: The objectives of this study were to investigate the prevalence of sIgE to galactose-α-1,3-galactose (α-gal) in individuals with acute urticaria or anaphylaxis from different geographical areas of Spain and to evaluate the relevance of demographics and lifestyle as risk factors for this immune response. Methods: Participants were recruited from allergy departments at 14 Spanish hospitals. Patients aged 18 years or older presenting with urticaria or anaphylaxis were enrolled into one of 2 arms: cases and controls. An interviewer-administered questionnaire collecting demographic data, lifestyle habits, and the presence of cofactors was obtained from each participant. sIgE to α-gal and total IgE were determined using ImmunoCAP. sIgE levels ≥0.35 kU/L were considered a positive result. Results: The study population comprised 160 cases and 126 controls. The median age was 44 years. The overall prevalence of a positive result of sIgE to α-gal was 15.7%; this was higher in cases (26.3%) than in controls (2.4%). The sIgE anti-α-gal positivity rate ranged from 37.68% (rural) to 15.38% (semiurban), and 7.85% (urban). The rates of positivity were 46.32%, (Northern), 0.72% (Center), and 0% (Mediterranean). A positive result for sIgE to α-gal was associated with a history of tick bites, participation in outdoor activities, pet ownership, and ingestion of mammalian meats or innards before the onset of symptoms. Only alcohol consumption could be implicated as a cofactor. Conclusion: Sensitization to α-gal in patients with urticaria or anaphylaxis differs considerably between the 3 geographical areas studied and is related to tick bites.
Databáze:	MEDLINE
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