Neuropsychiatric symptoms following sore throat in a young boy.
| Autor: | Jadah RHS; Department of Pediatrics, Bahrain Defence Force Royal Medical Services, Riffa, Bahrain., Mujeeb AA; Department of Pediatrics, Jawaharlal Nehru Medical College, Aligarh, Uttar Pradesh, India. |
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| Jazyk: | angličtina |
| Zdroj: | BMJ case reports [BMJ Case Rep] 2019 Jan 22; Vol. 12 (1). Date of Electronic Publication: 2019 Jan 22. |
| DOI: | 10.1136/bcr-2018-227540 |
| Abstrakt: | A previously healthy 6-year-old boy was referred to us by his primary provider, with a history of sudden onset behavioural abnormalities including irritability, sleep disturbance and anxiety. Physical examination revealed no significant findings; further analyses were not suggestive of meningitis, encephalitis, metabolic abnormalities, toxicity or any other obvious cause. On rechecking the patient's history, an episode of throat pain 1 week prior to the symptom onset was noted. Therefore, the possibility of paediatric autoimmune neuropsychiatric disorders associated with streptococcal infections (PANDAS) was considered. The antistreptolysin O titre was high (1078 IU/mL), and it increased to 1194 IU/mL 4 weeks later, leading to a diagnosis of PANDAS. He was started on ampicillin and administered one dose of intravenous immunoglobulin. His abnormal behaviours subsided and he returned to a normal state within 48 hours of treatment. This report aims to provide insights into the symptomology and diagnosis of PANDAS in children. Competing Interests: Competing interests: None declared. (© BMJ Publishing Group Limited 2019. No commercial re-use. See rights and permissions. Published by BMJ.) |
| Databáze: | MEDLINE |
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