Impact of different image reconstructions on PET quantification in non-small cell lung cancer: a comparison of adenocarcinoma and squamous cell carcinoma.
Autor: | Messerli M; 1 Department of Nuclear Medicine, University Hospital Zurich / University of Zurich , Switzerland., Kotasidis F; 2 GE Healthcare , Waukesha, WI , USA., Burger IA; 1 Department of Nuclear Medicine, University Hospital Zurich / University of Zurich , Switzerland., Ferraro DA; 1 Department of Nuclear Medicine, University Hospital Zurich / University of Zurich , Switzerland., Muehlematter UJ; 1 Department of Nuclear Medicine, University Hospital Zurich / University of Zurich , Switzerland.; 3 Institute of Diagnostic and Interventional Radiology, University Hospital Zurich / University of Zurich , Switzerland., Weyermann C; 1 Department of Nuclear Medicine, University Hospital Zurich / University of Zurich , Switzerland., Kenkel D; 1 Department of Nuclear Medicine, University Hospital Zurich / University of Zurich , Switzerland.; 3 Institute of Diagnostic and Interventional Radiology, University Hospital Zurich / University of Zurich , Switzerland., von Schulthess GK; 1 Department of Nuclear Medicine, University Hospital Zurich / University of Zurich , Switzerland., Kaufmann PA; 1 Department of Nuclear Medicine, University Hospital Zurich / University of Zurich , Switzerland., Huellner MW; 1 Department of Nuclear Medicine, University Hospital Zurich / University of Zurich , Switzerland. |
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Jazyk: | angličtina |
Zdroj: | The British journal of radiology [Br J Radiol] 2019 Apr; Vol. 92 (1096), pp. 20180792. Date of Electronic Publication: 2019 Feb 26. |
DOI: | 10.1259/bjr.20180792 |
Abstrakt: | Objective:: Positron emission tomography (PET) using 18 F-fludeoxyglucose ( 18 F-FDG) is an established imaging modality for tumor staging in patients with non-small cell lung cancer (NSCLC). There is a growing interest in using 18 F-FDG PET for therapy response assessment in NSCLC which relies on quantitative PET parameters such as standardized uptake values (SUV). Different reconstruction algorithms in PET may affect SUV. We sought to determine the variation of SUV in patients with NSCLC when using ordered subset expectation maximization (OSEM) and block sequential regularized expectation maximization (BSREM) in latest-generation digital PET/CT, including a subanalysis for adenocarcinoma and squamous cell carcinoma. Methods:: A total of 58 patients (34 = adenocarcinoma, 24 = squamous cell carcinoma) who underwent a clinically indicated 18 F-FDG PET/CT for staging were reviewed. PET images were reconstructed with OSEM and BSREM reconstruction with noise penalty strength β-levels of 350, 450, 600, 800 and 1200. Lung tumors maximum standardized uptake value (SUV Results:: Lung tumors SUV Conclusion:: In NSCLC the relative change of SUV when using BSREM instead of OSEM is significantly higher in adenocarcinoma as compared to squamous cell carcinoma. Advances in Knowledge:: The impact of BSREM on SUV may vary in different histological subtypes of NSCLC. This highlights the importance for careful standardization of β-value used for serial 18 F-FDG PET scans when following-up NSCLC patients. |
Databáze: | MEDLINE |
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