[The NT-proBNP in saliva and blood serum in norm and under periodontitis.]

Autor:	Sosnin DY; The Federal State Budget Educational Institution of Higher Education 'Е.A. Wagner Perm State Medical University' Ministry of Health of Russia, 614990, Perm, Russia., Gileva OS; The Federal State Budget Educational Institution of Higher Education 'Е.A. Wagner Perm State Medical University' Ministry of Health of Russia, 614990, Perm, Russia., Mozgovaia LA; The Federal State Budget Educational Institution of Higher Education 'Е.A. Wagner Perm State Medical University' Ministry of Health of Russia, 614990, Perm, Russia., Sivak EY; The Federal State Budget Educational Institution of Higher Education 'Е.A. Wagner Perm State Medical University' Ministry of Health of Russia, 614990, Perm, Russia., Beleva NS; The Federal State Budget Educational Institution of Higher Education 'Е.A. Wagner Perm State Medical University' Ministry of Health of Russia, 614990, Perm, Russia., Krivtsov AV; The Federal Budget Institution of Science 'The Federal Scientific Center of Medical Preventive Technologies of Management of Population Health Risks' of Rospotrebnadzor of Russia, 614000, Perm, Russia., Pozdin NV; The Federal State Budget Educational Institution of Higher Education 'The Perm National Research Polytechnic University', 614990, Perm, Russia.
Jazyk:	ruština
Zdroj:	Klinicheskaia laboratornaia diagnostika [Klin Lab Diagn] 2018; Vol. 63 (3), pp. 164-168.
DOI:	10.18821/0869-2084-2018-63-3-164-168
Abstrakt:	The concentration of NT-proBNP in saliva and blood serum was studied. The study included 58 individuals divided in two groups. The main group (group I) included 34 patients with chronic generalized periodontitis. The control group (group II), comparable in age and gender, included 24 examined individuals without signs of inflammatory diseases of oral cavity. The concentration of NT-proBNP in saliva and blood serum was detected by technique of solid-phase enzyme immunoassay using the test-system "NT-proBNP-ELISABEST" (Vector-Best, Russia). The concentration of NT-proBNP in saliva of patients of main group reliably exceeded its concentration in saliva of the examined from control group. The median and interquartile range made up to correspondingly 178.5 (128-253) pg / ml in main group and 105 (72.5 - 144.5) pg, respectively / ml in control group (p = 0.02). The comparison of concentration of NT-proBNP in blood serum samples established no reliable differences (p = 0,27). The evaluation of the relationship between content of NT-proBNP in saliva and blood serum demonstrated absence of close linear correlation dependence between the concentration of this compound in blood serum and saliva both in the main group (R = 0.143, p = 0.419) and the control group (R = 0.178; p = 0.405), and for all the examined as well (R = 0.252, p = 0.056). The higher concentration of NT-proBNP in saliva in comparison with blood serum can be explained by formation of proteolysis products cross-reacting in the used system. Competing Interests: The authors declare no conflict of interest.
Databáze:	MEDLINE
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