[The choice of antibiotic according the results of standard bacteriological analysis and express-method without isolation of pure cultures.]

Autor:	Tetz VV; The Federal State Budget Educational Institution of Higher Education 'The Pavlov First Saint Petersburg State Medical University' of Minzdrav of Russia, 197022, St. Petersburg, Russia., Tetz GV; The Federal State Budget Educational Institution of Higher Education 'The Pavlov First Saint Petersburg State Medical University' of Minzdrav of Russia, 197022, St. Petersburg, Russia., Smirnova EI; The Federal State Budget Educational Institution of Higher Education 'The Pavlov First Saint Petersburg State Medical University' of Minzdrav of Russia, 197022, St. Petersburg, Russia., Zaslavskaya NV; The Federal State Budget Educational Institution of Higher Education 'The Pavlov First Saint Petersburg State Medical University' of Minzdrav of Russia, 197022, St. Petersburg, Russia., Vikina DS; The Federal State Budget Educational Institution of Higher Education 'The Pavlov First Saint Petersburg State Medical University' of Minzdrav of Russia, 197022, St. Petersburg, Russia., Artemenko NK; The Federal State Budget Educational Institution of Higher Education 'The Pavlov First Saint Petersburg State Medical University' of Minzdrav of Russia, 197022, St. Petersburg, Russia., Vecherkovskaya MF; The Federal State Budget Educational Institution of Higher Education 'The Pavlov First Saint Petersburg State Medical University' of Minzdrav of Russia, 197022, St. Petersburg, Russia., Kazakov SP; The Federal State Official Institution 'The N.N. Burdenko Main Military Clinical Hospital' of ministry of Defense of Russia, 105229, Moscow, Russia., Putkov SB; The Federal State Official Institution 'The N.N. Burdenko Main Military Clinical Hospital' of ministry of Defense of Russia, 105229, Moscow, Russia., Esaulenko NB; The Federal State Official Institution 'The N.N. Burdenko Main Military Clinical Hospital' of ministry of Defense of Russia, 105229, Moscow, Russia., Tugarina TV; The Federal State Official Institution 'The N.N. Burdenko Main Military Clinical Hospital' of ministry of Defense of Russia, 105229, Moscow, Russia.
Jazyk:	ruština
Zdroj:	Klinicheskaia laboratornaia diagnostika [Klin Lab Diagn] 2018; Vol. 63 (2), pp. 106-109.
DOI:	10.18821/0869-2084-2018-63-2-106-109
Abstrakt:	The efficiency of choosing antibiotics using two methods was analyzed. The first method is based on standard laboratory analysis including isolation of pure cultures of prospective agent and detection of their individual sensitivity to antibiotics. The second method is based on a new express-technique permitting to simultaneously evaluate effect of pharmaceuticals on cultivated and not cultivated yet bacteria without isolation of pure cultures. At that, the second method permits to determine efficiency of antibiotics namely in those concentrations that can be made in the given nidus of infection. The study demonstrated existence of discrepancy between results obtained by using the given methods. The cause of discrepancy can be presence of not cultivated yet bacteria in pathologic sample. In favor of this assumption testify the received data concerning samples from patients where were presented a significant number of spore-former bacteria having additional mechanisms of resistance to antibiotics. Furthermore, the implemented study established antibiotics characterized by the greatest discrepancy of results obtained by applied methods that indicates the necessity of revision of schemes of implementation of start or empiric therapy. Competing Interests: The authors declare no conflict of interest.
Databáze:	MEDLINE
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