[The main metabolites ferrokinetics in differential diagnostic of anemic syndrome with microcytic, hypochromic characteristics of erythrocytes in patients with colorectal cancer.]

Autor:	Blindar VN; FGBU 'National Medical Research Center of Oncology N.N. Blokhin' of the Ministry of the Health of Russia, 115478, Moscow, Russia., Zubrikhina GN; FGBU 'National Medical Research Center of Oncology N.N. Blokhin' of the Ministry of the Health of Russia, 115478, Moscow, Russia., Matveeva II; FGBU 'National Medical Research Center of Oncology N.N. Blokhin' of the Ministry of the Health of Russia, 115478, Moscow, Russia.
Jazyk:	ruština
Zdroj:	Klinicheskaia laboratornaia diagnostika [Klin Lab Diagn] 2018; Vol. 63 (2), pp. 89-94.
DOI:	10.18821/0869-2084-2018-63-2-89-94
Abstrakt:	The clinical analysis of blood and main metabolites of ferrokinetics was implemented before treatment in 46 patients with colorectal cancer mainly in stage III-IV. The analysis of obtained results demonstrated that the technique of detection of hepcidin 25 can be used as an additional diagnostic criterion of anemic syndrome in complex with ferritin, soluble receptors of transferrin and expanded clinical analysis of blood. This is especially important in differential diagnostic of anemia of chronic diseas combined with iron-deficiency anemia and anemia of chronic disease with functional iron deficiency because treatment differs in the main. The perspective consists in pathogenic approach to treatment of anemia of chronic disease in oncologic patients using anti-hepcidin medications on the basis of antibodies to hormone, inhibitors and blockers of its expression under control of concentration of hepcidin. Competing Interests: The authors declare no conflict of interest.
Databáze:	MEDLINE
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