Self-Healing Polymeric Hydrogel Formed by Metal-Ligand Coordination Assembly: Design, Fabrication, and Biomedical Applications.

Autor: Shi L; State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Biology, Hunan University, Changsha, 410082, China.; Division of Polymer Chemistry, Department of Chemistry-Ångström, Uppsala University, Uppsala, 75121, Sweden., Ding P; State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Biology, Hunan University, Changsha, 410082, China., Wang Y; State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical Engineering, Hunan University, Changsha, 410082, China., Zhang Y; College of Chemistry and Materials Science, Northwest University, Xi'an, Shaanxi, 710069, China., Ossipov D; Department of Biosciences and Nutrition, Karolinska Institute, Häsovägen 7c,, Huddinge, 14157, Sweden., Hilborn J; Division of Polymer Chemistry, Department of Chemistry-Ångström, Uppsala University, Uppsala, 75121, Sweden.
Jazyk: angličtina
Zdroj: Macromolecular rapid communications [Macromol Rapid Commun] 2019 Apr; Vol. 40 (7), pp. e1800837. Date of Electronic Publication: 2019 Jan 23.
DOI: 10.1002/marc.201800837
Abstrakt: Self-healing hydrogels based on metal-ligand coordination chemistry provide new and exciting properties that improve injectability, rheological behaviors, and even biological functionalities. The inherent reversibility of coordination bonds improves on the covalent cross-linking employed previously, allowing for the preparation of completely self-healing hydrogels. In this article, recent advances in the development of this class of hydrogels are summarized and their applications in biology and medicine are discussed. Various chelating ligands such as bisphosphonate, catechol, histidine, thiolate, carboxylate, pyridines (including bipyridine and terpyridine), and iminodiacetate conjugated onto polymeric backbones, as well as the chelated metal ions and metal ions containing inorganic particles, which are used to form dynamic networks, are highlighted. This article provides general ideas and methods for the design of self-healing hydrogel biomaterials based on coordination chemistry.
(© 2019 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.)
Databáze: MEDLINE
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