| Autor: |
Amaro-Gahete FJ; EFFECTS-262 Research Group, Department of Physiology, School of Medicine, University of Granada, Granada, Spain.; PROmoting FITness and Health Through Physical Activity Research Group (PROFITH), Department of Physical Education and Sports, Faculty of Sport Sciences, University of Granada, Granada, Spain., De-la-O A; EFFECTS-262 Research Group, Department of Physiology, School of Medicine, University of Granada, Granada, Spain., Jurado-Fasoli L; EFFECTS-262 Research Group, Department of Physiology, School of Medicine, University of Granada, Granada, Spain., Espuch-Oliver A; Clinical Laboratory Service, 'Virgen de las Nieves' University Hospital, Granada, Spain., de Haro T; Clinical Laboratory Service, 'San Cecilio' University Hospital, Granada, Spain., Gutiérrez Á; EFFECTS-262 Research Group, Department of Physiology, School of Medicine, University of Granada, Granada, Spain., Ruiz JR; PROmoting FITness and Health Through Physical Activity Research Group (PROFITH), Department of Physical Education and Sports, Faculty of Sport Sciences, University of Granada, Granada, Spain., Castillo MJ; EFFECTS-262 Research Group, Department of Physiology, School of Medicine, University of Granada, Granada, Spain. |
| Abstrakt: |
The α-Klotho gene was identified as a possible "aging-suppressor" agent that extends life span when overexpressed. However, little is known about the association of the body composition with the secreted protein form of the α-Klotho gene (S-Klotho). Therefore, the aim of this study was to analyze the association of body composition, including lean and fat mass as well as bone mineral density (BMD), with S-Klotho plasma levels in middle-aged sedentary adults. A total of 74 (39 women) middle-aged sedentary adults (53.7 ± 5.1 years old; 75.7 ± 14.0 kg; 167.8 ± 9.8 cm) participated in the study. We measured weight and height, and we used dual-energy X-ray absorptiometry to measure fat mass and lean mass. We calculated the body mass index (BMI), fat mass index (FMI), and lean mass index (LMI). The S-Klotho plasma levels were measured in the ethylenediaminetetraacetic acid plasma using a solid-phase sandwich enzyme-linked immunosorbent assay. There was a strong positive association between LMI and S-Klotho plasma levels ( β = 74.794, R 2 = 0.346, p < 0.001), which persisted after controlling for age and gender as well as after additionally controlling for FMI. Significantly positive associations of BMI and BMD were also found with S-Klotho plasma levels ( β = 33.981, R 2 = 0.125, p = 0.002 and β = 858.194, R 2 = 0.058, p = 0.041, respectively), which disappeared after controlling for LMI ( β = 0.183, R 2 = 0.611, p = 0.984 and β = -379.426, R 2 = 0.617, p = 0.290, respectively). FMI was not significantly associated with S-Klotho plasma levels. Our study shows that LMI is strongly associated with S-Klotho plasma levels and explains the associations of BMI and BMD with S-Klotho plasma levels in middle-aged sedentary adults. |
