Clinical characteristics of a large cohort of patients with positive culture of Fusobacterium necrophorum.

Autor:	Klasinc R; Department of Infection Control & Hospital Epidemiology, Medical University of Vienna, Austria.; Institute for Hygiene and Applied Immunology, Center for Pathophysiology, Infectiology and Immunology, Medical University of Vienna, Austria., Lupyr K; Department of Infection Control & Hospital Epidemiology, Medical University of Vienna, Austria., Zeller I; Division of Clinical Microbiology, Department of Laboratory Medicine, Medical University of Vienna, Austria., Paula H; Department of Infection Control & Hospital Epidemiology, Medical University of Vienna, Austria., Makristathis A; Division of Clinical Microbiology, Department of Laboratory Medicine, Medical University of Vienna, Austria., Tuchmann F; Department of Dermatology, Medical University of Vienna, Austria., Wrba T; Medical University of Vienna, IT4Science, IT-Systems & Communications, Vienna, Austria., Assadian O; Department of Infection Control & Hospital Epidemiology, Medical University of Vienna, Austria., Presterl E; Department of Infection Control & Hospital Epidemiology, Medical University of Vienna, Austria.
Jazyk:	angličtina
Zdroj:	GMS infectious diseases [GMS Infect Dis] 2018 Mar 07; Vol. 6, pp. Doc03. Date of Electronic Publication: 2018 Mar 07 (Print Publication: 2018).
DOI:	10.3205/id000038
Abstrakt:	Background: Fusobacterium necrophorum is a rare pathogen, mostly affecting young adults, causing infections of the head and neck, typically described as the Lemierre's syndrome. Today this symptom complex has become increasingly rare and has almost turned to a 'forgotten disease'. Methods: We performed a retrospective, descriptive study to identify the clinical features of patients with positive culture of F. necrophorum . Additionally, the antibiotic susceptibility profile of the pathogens was analysed. Results: During a period of 22 years 36 patients with at least one isolate of F. necrophorum were identified. Mostly tonsillar and peritonsillar abscesses were found, 10 patients were identified with bacteraemia, but only 4 patients presented with symptoms like sore throat, fever and swollen cervical lymph nodes, which may suggest Lemierre's. Most of the isolates (33/35) showed sensitivity to all tested antibiotics. Conclusion: Appropriate techniques are needed to detect F. necropho rum , especially from throat swabs, in the microbiological laboratory. Current clinical and microbiological practice may lead to under-diagnosis of infections caused by F. necrophorum . Further research is needed to define the colonization rate and to optimize methods for detection as well as identification of virulence. Competing Interests: The authors declare that they have no competing interests.
Databáze:	MEDLINE
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