Evaluation of anti-HSV-1 activity and toxicity of hydroethanolic extract of Tanacetum parthenium (L.) Sch.Bip. (Asteraceae).

Autor: Benassi-Zanqueta É; Department of Basic Health Sciences, State University of Maringá, Maringá, Paraná, Brazil., Marques CF; Department of Basic Health Sciences, State University of Maringá, Maringá, Paraná, Brazil., Valone LM; Department of Basic Health Sciences, State University of Maringá, Maringá, Paraná, Brazil., Pellegrini BL; Department of Pharmacy, State University of Maringá, Maringá, Paraná, Brazil., Bauermeister A; Department of Physics and Chemistry, University of São Paulo, Ribeirão Preto, São Paulo, Brazil., Ferreira ICP; Department of Pharmacy, State University of Maringá, Maringá, Paraná, Brazil., Lopes NP; Department of Physics and Chemistry, University of São Paulo, Ribeirão Preto, São Paulo, Brazil., Nakamura CV; Department of Basic Health Sciences, State University of Maringá, Maringá, Paraná, Brazil., Dias Filho BP; Department of Basic Health Sciences, State University of Maringá, Maringá, Paraná, Brazil., Natali MRM; Department of Morphological Sciences, State University of Maringá, Maringá, Paraná, Brazil., Ueda-Nakamura T; Department of Basic Health Sciences, State University of Maringá, Maringá, Paraná, Brazil. Electronic address: tunakamura@uem.br.
Jazyk: angličtina
Zdroj: Phytomedicine : international journal of phytotherapy and phytopharmacology [Phytomedicine] 2019 Mar 01; Vol. 55, pp. 249-254. Date of Electronic Publication: 2018 Aug 13.
DOI: 10.1016/j.phymed.2018.06.040
Abstrakt: Background: Herpes simplex type 1 (HSV-1) is widely distributed throughout the world's population. The virus spreads through direct contact with an infected individual. After primary infection, the virus remains in a latent state, and the recurrence of herpetic lesions is common. Standard treatment is performed with nucleoside analogues, but the selection of resistant strains have occurred, thus requiring the continual search for new antiviral agents. Plant extracts, fractions, and isolated compounds are a good source for studying possible antiviral compounds.
Hypothesis: Among plants with antiviral activity, the crude extract of aerial parts of Tanacetum parthenium (L.) Sch.Bip. (Asteraceae) have previously shown to inhibit HSV-1 infection in vitro.
Methods: The present study investigated the chemical composition of a crude hydroethanolic extract (CHE) of T. parthenium, and in vivo safety and therapeutic efficacy against HSV-1 infection.
Results: Liquid chromatography-mass spectrometry showed that the CHE was composed of phenolic acids (chlorogenic acids) and sesquiterpene lactones (parthenolide). Acute and subchronic toxicity and genotoxicity tests in vivo showed that oral CHE administration did not result in signs of toxicity, with no genotoxic potential. The CHE was also safe for topical administration, in which no irritation of the epidermis was observed in treated animals. Tests of topical and oral therapeutic efficacy showed that the CHE was effective against HSV-1 infection. Topical administration was the most effective, the results for which were comparable to acyclovir.
Conclusion: These findings indicate that the CHE from aerial parts of Tanacetum parthenium has in vivo anti-HSV-1 activity and is safe for oral and topical application.
(Copyright © 2018 Elsevier GmbH. All rights reserved.)
Databáze: MEDLINE
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