Youth-Onset Type 2 Diabetes and the Developing Brain.

Autor: Redel JM; Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH, USA. Jacob.Redel@cchmc.org.; Division of Endocrinology, Cincinnati Children's Hospital Medical Center, 3333 Burnet Ave. MLC 7012, Cincinnati, OH, 45229, USA. Jacob.Redel@cchmc.org., Dolan LM; Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH, USA.; Division of Endocrinology, Cincinnati Children's Hospital Medical Center, 3333 Burnet Ave. MLC 7012, Cincinnati, OH, 45229, USA., DiFrancesco M; Department of Radiology, University of Cincinnati College of Medicine, Cincinnati, OH, USA.; Pediatric Neuroimaging Research Consortium, Cincinnati Children's Hospital Medical Center, 3333 Burnet Ave, Cincinnati, OH, 45229, USA., Vannest J; Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH, USA.; Pediatric Neuroimaging Research Consortium, Cincinnati Children's Hospital Medical Center, 3333 Burnet Ave, Cincinnati, OH, 45229, USA.; Division of Neurology, Cincinnati Children's Hospital Medical Center, 3333 Burnet Ave., Cincinnati, OH, 45229, USA., Shah AS; Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH, USA.; Division of Endocrinology, Cincinnati Children's Hospital Medical Center, 3333 Burnet Ave. MLC 7012, Cincinnati, OH, 45229, USA.
Jazyk: angličtina
Zdroj: Current diabetes reports [Curr Diab Rep] 2019 Jan 21; Vol. 19 (1), pp. 3. Date of Electronic Publication: 2019 Jan 21.
DOI: 10.1007/s11892-019-1120-y
Abstrakt: Purpose of Review: This review describes the literature evaluating the potential adverse effects of youth-onset type 2 diabetes on the developing brain. A summary of recently published articles and the current state of knowledge are covered succinctly in this manuscript.
Recent Findings: Current literature suggests both cognitive and brain structural differences are found in youth with type 2 diabetes. Studies have shown poorer scores in a number of neurocognitive domains, particularly in areas of executive functioning and memory. Additionally, imaging studies have found differences in brain gray matter volume, white matter volume, and microstructural integrity. These findings are largely consistent with the adult literature. Youth with type 2 diabetes demonstrate lower cognitive scores and structural brain differences. Although causality has not yet been established, these findings are important because these individuals are still undergoing neurodevelopmental maturation.
Databáze: MEDLINE
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