Short-term antidepressant treatment has long-lasting effects, and reverses stress-induced decreases in bone features in rats.

Autor:	Lee SH; John Curtin School of Medical Research, College of Health and Medicine, Australian National University, Canberra, ACT, 0200, Australia.; Section on Neural Gene Expression, National Institute of Mental Health, Building 49, Room 5A51, 49 Convent Drive, Bethesda, MD, 20892, USA., Mastronardi CA; John Curtin School of Medical Research, College of Health and Medicine, Australian National University, Canberra, ACT, 0200, Australia.; Neuroscience Group (NeUROS), Institute of Translational Medicine, School of Medicine and Health Sciences, Universidad del Rosario, Bogotá, Colombia., Li RW; Trauma and Orthopaedic Research Laboratory, Department of Surgery, Medical School, Australian National University, Canberra, ACT, 0200, Australia., Paz-Filho G; John Curtin School of Medical Research, College of Health and Medicine, Australian National University, Canberra, ACT, 0200, Australia.; Janssen Australia, 1-5 Khartoum Rd, North Ryde, NSW, 2113, Australia., Dutcher EG; Mind & Brain Theme, South Australian Health and Medical Research, Adelaide, PO Box 11060, Adelaide, SA, 5001, Australia.; School of Medicine, University of Adelaide, Adelaide, SA, 5005, Australia., Lewis MD; Mind & Brain Theme, South Australian Health and Medical Research, Adelaide, PO Box 11060, Adelaide, SA, 5001, Australia.; Flinders University College of Medicine and Public Health, Bedford Park, SA, 5042, Australia., Vincent AD; Freemasons Foundation Centre for Men's Health, Department of Medicine, School of Medicine, University of Adelaide, Adelaide, SA, 5005, Australia., Smith PN; Trauma and Orthopaedic Research Laboratory, Department of Surgery, Medical School, Australian National University, Canberra, ACT, 0200, Australia.; Clinical Orthopaedic Surgery, The Canberra Hospital, Yamba Drive, Garran, ACT, 2605, Australia., Bornstein SR; Medical Clinic III, Carl Gustav Carus University Hospital, Dresden University of Technology, Fetscherstraβe 74, 01307, Dresden, Germany., Licinio J; Mind & Brain Theme, South Australian Health and Medical Research, Adelaide, PO Box 11060, Adelaide, SA, 5001, Australia. LicinioJ@upstate.edu.; Flinders University College of Medicine and Public Health, Bedford Park, SA, 5042, Australia. LicinioJ@upstate.edu.; State of New York University, Upstate Medical University, Office of the Dean of Medicine, Room 1256 Weiskottem Hall, 766 Irving Ave, Syracuse, NY, 13210, USA. LicinioJ@upstate.edu., Wong ML; Mind & Brain Theme, South Australian Health and Medical Research, Adelaide, PO Box 11060, Adelaide, SA, 5001, Australia. wongma@upstate.edu.; Flinders University College of Medicine and Public Health, Bedford Park, SA, 5042, Australia. wongma@upstate.edu.; State of New York, Upstate Medical University, 3738C NRB 505 Irving Ave, Syracuse, NY, 13210, USA. wongma@upstate.edu.
Jazyk:	angličtina
Zdroj:	Translational psychiatry [Transl Psychiatry] 2019 Jan 16; Vol. 9 (1), pp. 10. Date of Electronic Publication: 2019 Jan 16.
DOI:	10.1038/s41398-018-0351-z
Abstrakt:	Antidepressants are among the most-prescribed class of drugs in the world and though weight gain is a common outcome of antidepressant treatment, that effect is not well understood. We employed an animal model comprised of 2 weeks of chronic restraint stress with antidepressant treatment, followed by diet-induced obesity. We showed that short-term antidepressant treatment had long-lasting effects, not only leading to weight gain, but also enhancing trabecular and cortical bone features in rats; therefore, weight gain in this model was different from that of the classic diet-induced obesity. Late in the post-restraint recovery period, antidepressant-treated animals were significantly heavier and had better bone features than saline-treated controls, when assessed in the distal femoral metaphysis. The propensity to gain weight might have influenced the rate of catch-up growth and bone allometry, as heavier animals treated with fluoxetine also had enhanced bone features when compared to non-stressed animals. Therefore, short-term antidepressant treatment ameliorated the long-term effects of stress on body growth and bone. Growth and bone structural features were associated with leptin levels, and the interaction between leptin levels and antidepressant was significant for bone mineral content, suggesting that short-term antidepressants in the context of long-term diet-induced obesity modified the role of leptin in bone formation. To our knowledge this is the first study reporting that short-term antidepressant treatment has long-lasting effects in restoring the effects of chronic stress in body weight and bone formation. Our findings may be relevant to the understanding and treatment of osteoporosis, a condition of increasing prevalence due to the aging population.
Databáze:	MEDLINE
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