Management of Symmetrical Peripheral Gangrene.

Autor: Foead AI; Department of Orthopedics, School of Medicine, Perdana University-Royal College of Surgeons Ireland Selangor, Malaysia., Mathialagan A; Department of Pharmacology, School of Medicine, Perdana University-Royal College of Surgeons Ireland Selangor, Malaysia., Varadarajan R; Department of Surgery, School of Medicine, Perdana University-Royal College of Surgeons Ireland Selangor, Malaysia., Larvin M; Department of Surgery, School of Medicine, Perdana University-Royal College of Surgeons Ireland Selangor, Malaysia.
Jazyk: angličtina
Zdroj: Indian journal of critical care medicine : peer-reviewed, official publication of Indian Society of Critical Care Medicine [Indian J Crit Care Med] 2018 Dec; Vol. 22 (12), pp. 870-874.
DOI: 10.4103/ijccm.IJCCM_379_18
Abstrakt: Symmetrical peripheral gangrene (SPG) is a rare, debilitating disease that deserves more widespread concern among the medical fraternities. The objective of this review is to outline the etiology, pathology findings, and management practices of SPG. About 18%-40% mortality rate was reported, and survivors have high frequency of multiple limb amputations. SPG is the hallmark of disseminated intravascular coagulation (DIC). The main pathogenesis theory, to date, is microthrombosis associated with disturbed procoagulant-anticoagulant balance. The treatment of SPG is largely anecdotal and theoretically involves heparin-based anticoagulation and substitution of natural anticoagulants. Early recognition, prompt management of DIC, and underlying conditions may halt the progression of the disease. The multicenter randomized controlled trial should be set up to formulate the proper treatment guidelines.
Competing Interests: There are no conflicts of interest.
Databáze: MEDLINE
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