Systemic calprotectin and chronic inflammatory rheumatic diseases.

Autor: Romand X; GREPI, EA 7408, University Grenoble Alpes, 38700 La Tronche, France., Bernardy C; GREPI, EA 7408, University Grenoble Alpes, 38700 La Tronche, France. Electronic address: cbernardy@chu-grenoble.fr., Nguyen MVC; GREPI, EA 7408, University Grenoble Alpes, 38700 La Tronche, France; Sinnovial SAS, avenue de Kimberley, 38130 Échirolles, France., Courtier A; Sinnovial SAS, avenue de Kimberley, 38130 Échirolles, France., Trocme C; TIMC-IMAG laboratory UMR 5525, CNRS, university Grenoble Alpes, 38041 Grenoble, France; Centre hospitalier universitaire Grenoble Alpes, hôpital Michallon Pôle biologie, laboratoire de biochimie des enzymes et des protéines, 38700 La Tronche, France., Clapasson M; GREPI, EA 7408, University Grenoble Alpes, 38700 La Tronche, France., Paclet MH; GREPI, EA 7408, University Grenoble Alpes, 38700 La Tronche, France; Centre hospitalier universitaire Grenoble Alpes, hôpital Michallon Pôle biologie, laboratoire de biochimie des enzymes et des protéines, 38700 La Tronche, France., Toussaint B; TIMC-IMAG laboratory UMR 5525, CNRS, university Grenoble Alpes, 38041 Grenoble, France; Centre hospitalier universitaire Grenoble Alpes, hôpital Michallon Pôle biologie, laboratoire de biochimie des enzymes et des protéines, 38700 La Tronche, France., Gaudin P; GREPI, EA 7408, University Grenoble Alpes, 38700 La Tronche, France; Sinnovial SAS, avenue de Kimberley, 38130 Échirolles, France., Baillet A; GREPI, EA 7408, University Grenoble Alpes, 38700 La Tronche, France; Sinnovial SAS, avenue de Kimberley, 38130 Échirolles, France.
Jazyk: angličtina
Zdroj: Joint bone spine [Joint Bone Spine] 2019 Nov; Vol. 86 (6), pp. 691-698. Date of Electronic Publication: 2019 Jan 17.
DOI: 10.1016/j.jbspin.2019.01.003
Abstrakt: Calprotectin is a calcium binding protein produced by neutrophils and monocytes locally at the site of inflammation in order to trigger the innate immunity receptors. This unique characteristic makes it a good proxy for evaluation of local inflammation in chronic inflammatory rheumatic diseases. Complete data suggest, in inflammatory rheumatic diseases, a relevant role of calprotectin in the inflammatory process. The interest of serum or plasma calprotectin dosage has been studied intensively, in the current years, especially in rheumatoid arthritis, spondyloarthritis, juvenile idiopathic arthritis and ANCA associated vasculitis. Calprotectin seems to be a great candidate as biomarker to assess and monitor disease activity, to predict structural progression or response to the treatment. Calprotectin showed its ability to predict radiological progression in rheumatoid arthritis and ankylosing spondylitis. Serum calprotectin can predict the risk of relapse in ANCA associated vasculitis and the risk of inflammatory bowel disease in spondyloarthritis. Nevertheless, studies report controversial result requiring replication in other large cohort. The lack of assay standardization between studies is a problem to replicate and compare studies. In this review, we discuss on the interest of systemic calprotectin in chronic inflammatory rheumatic disease as a diagnostic, activity or prognostic biomarker.
(Copyright © 2019 Société française de rhumatologie. Published by Elsevier Masson SAS. All rights reserved.)
Databáze: MEDLINE
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