Insulin resistance and NAFLD: Relationship with intrahepatic iron and serum TNF-α using 1H MR spectroscopy and MRI.

Autor: Martin-Rodriguez JL; Department of Radiology, University Hospital San Cecilio, Granada, Spain., Gonzalez-Cantero J; Department of Radiology, HGU Gregorio Marañon Madrid, and University of Granada, Spain. Electronic address: jorgegonzalezcantero@gmail.com., Gonzalez-Cantero A; Complejo Hospitalario de Toledo, Toledo, Castilla-La Mancha, Spain., Martí-Bonmatí L; Medical Imaging Department and Biomedical Imaging Research Group, Hospital Universitario y Politécnico La Fe and Instituto de Investigación Sanitaria La Fe, Valencia, Spain., Alberich-Bayarri Á; Grupo de Investigación Biomédica en Imagen, Instituto de Investigación Sanitaria La Fe and Quantitative Imaging Biomarkers in Medicine (QUIBIM), Valencia, Spain., Gonzalez-Cejudo T; Servicio Laboratorio Clínico, University Hospital San Cecilio, Granada, Spain., Gonzalez-Calvin JL; Department of Gastroenterology, University Hospital San Cecilio, Department of Medicine, University of Granada, Spain.
Jazyk: angličtina
Zdroj: Diabetes & metabolism [Diabetes Metab] 2019 Oct; Vol. 45 (5), pp. 473-479. Date of Electronic Publication: 2019 Jan 17.
DOI: 10.1016/j.diabet.2019.01.005
Abstrakt: Aim: The association of non-alcoholic fatty liver disease (NAFLD) with insulin resistance (IR) is well established, yet little is known of their possible relationship with intrahepatic iron and serum tumour necrosis factor (TNF)-α concentrations in adults without diabetes. Thus, this study looked at the relationship of intrahepatic iron and serum TNF-α with intrahepatic triglycerides and IR in non-diabetic adults.
Methods: In this cross-sectional study of 104 healthy non-diabetic Caucasians, a quantitative magnetic resonance (MR) imaging T2 gradient-echo technique was used to measure hepatic iron, with 1H-MR spectroscopy used to measure hepatic triglycerides. HOMA-IR was calculated to determine IR.
Results: The prevalence of hepatic iron overload (HIOL) was 26.6% in individuals with NAFLD vs. 0% in those without. IR was present in 87.5% of subjects with both NAFLD and HIOL, in 45.4% of those with NAFLD but not HIOL, and in 4.5% of those with neither. HOMA-IR was positively correlated with hepatic triglycerides (r = 0.56, P < 0.001) and hepatic iron (r = 0.52, P < 0.001), whereas serum TNF-α concentrations correlated with intrahepatic triglyceride levels (r = 0.28, P < 0.04), but not with intrahepatic iron. Hepatic triglycerides, serum TNF-α and age were the only significant determinants of IR in regression analyses.
Conclusion: IR is closely associated with intrahepatic triglycerides and, to a lesser extent, intrahepatic iron, with some interplay between them. High serum TNF-α concentrations may contribute to the association between NAFLD and IR, while increased hepatic triglycerides appear to be a determinant of the development of HIOL in non-diabetic subjects without haemochromatosis.
(Copyright © 2019 Elsevier Masson SAS. All rights reserved.)
Databáze: MEDLINE
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