Quantitative assessment of secondary white matter injury in the visual pathway by pituitary adenomas: a multimodal study at 7-Tesla MRI.

Autor:	Rutland JW; 1Translational and Molecular Imaging Institute and.; 4Neurosurgery, and., Padormo F; 1Translational and Molecular Imaging Institute and.; 2Guy's and St. Thomas' NHS Foundation Trust, London, United Kingdom., Yim CK; Departments of3Ophthalmology., Yao A; 4Neurosurgery, and., Arrighi-Allisan A; 4Neurosurgery, and., Huang KH; 1Translational and Molecular Imaging Institute and., Lin HM; 5Department of Population Health Science and Policy, Mount Sinai Hospital, New York, New York; and., Chelnis J; Departments of3Ophthalmology., Delman BN; 6Radiology, Icahn School of Medicine at Mount Sinai, New York; and., Shrivastava RK; 4Neurosurgery, and., Balchandani P; 1Translational and Molecular Imaging Institute and.
Jazyk:	angličtina
Zdroj:	Journal of neurosurgery [J Neurosurg] 2019 Jan 18; Vol. 132 (2), pp. 333-342. Date of Electronic Publication: 2019 Jan 18 (Print Publication: 2020).
DOI:	10.3171/2018.9.JNS182022
Abstrakt:	Objective: The objective of this study was to investigate microstructural damage caused by pituitary macroadenomas by performing probabilistic tractography of the optic tracts and radiations using 7-T diffusion-weighted MRI (DWI). These imaging findings were correlated with neuro-ophthalmological results to assess the utility of ultra-high-field MRI for objective evaluation of damage to the anterior and posterior visual pathways. Methods: Probabilistic tractography employing 7-T DWI was used to reconstruct the optic tracts and radiations in 18 patients with adenomas and in 16 healthy volunteers. Optic chiasm compression was found in 66.7% of the patients and visual defects in 61.1%. Diffusion indices were calculated along the projections and correlated with tumor volumes and results from neuro-ophthalmological examinations. Primary visual cortical thicknesses were also assessed. Results: Fractional anisotropy was reduced by 21.9% in the optic tracts (p < 0.001) and 17.7% in the optic radiations (p < 0.001) in patients with adenomas. Patients showed an 8.5% increase in mean diffusivity of optic radiations compared with healthy controls (p < 0.001). Primary visual cortical thickness was reduced in adenoma patients. Diffusion indices of the visual pathway showed significant correlations with neuro-ophthalmological examination findings. Conclusions: Imaging-based quantification of secondary neuronal damage from adenomas strongly correlated with neuro-ophthalmological findings. Diffusion characteristics enabled by ultra-high-field DWI may allow preoperative characterization of visual pathway damage in patients with chiasmatic compression and may inform prognosis for vision recoverability.
Databáze:	MEDLINE
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