BloodSurf 2017: News from the blood-biomaterial frontier.

Autor: Sotiri I; Department of Bioengineering, University of Washington, Seattle, WA 98150, USA., Robichaud M; Department of Systems Design Engineering, University of Waterloo, Waterloo, Ontario N2L 3G1, Canada., Lee D; Department of Bioengineering, University of Washington, Seattle, WA 98150, USA., Braune S; Institute of Biomaterial Science and Berlin-Brandenburg Center for Regenerative Therapies, Helmholtz-Zentrum Geesthacht (HZG), Teltow, Germany., Gorbet M; Department of Systems Design Engineering, University of Waterloo, Waterloo, Ontario N2L 3G1, Canada., Ratner BD; Department of Bioengineering, University of Washington, Seattle, WA 98150, USA; Department of Chemical Engineering, University of Washington, Seattle, WA 98150, USA., Brash JL; Department of Chemical Engineering, School of Biomedical Engineering, McMaster University, Hamilton, Ontario L8S 4L8, Canada., Latour RA; Department of Bioengineering, Clemson University, Clemson, SC 29634, USA. Electronic address: latourr@clemson.edu., Reviakine I; Department of Bioengineering, University of Washington, Seattle, WA 98150, USA. Electronic address: reviakin@uw.edu.
Jazyk: angličtina
Zdroj: Acta biomaterialia [Acta Biomater] 2019 Mar 15; Vol. 87, pp. 55-60. Date of Electronic Publication: 2019 Jan 17.
DOI: 10.1016/j.actbio.2019.01.032
Abstrakt: From stents and large-diameter vascular grafts, to mechanical heart valves and blood pumps, blood-contacting devices are enjoying significant clinical success owing to the application of systemic antiplatelet and anticoagulation therapies. On the contrary, research into material and device hemocompatibility aimed at alleviating the need for systemic therapies has suffered a decline. This research area is undergoing a renaissance fueled by recent fundamental insights into coagulation and inflammation that are offering new avenues of investigation, the growing recognition of the limitations facing existing therapeutic approaches, and the severity of the cardiovascular disorders epidemic. This Opinion article discusses clinical needs for hemocompatible materials and the emerging research directions for fulfilling those needs. Based on the 2017 BloodSurf conference that brought together clinicians, scientists, and engineers from academia, industry, and regulatory bodies, its purpose is to draw the attention of the wider clinical and scientific community to stimulate further growth. STATEMENT OF SIGNIFICANCE: The article highlights recent fundamental insights into coagulation, inflammation, and blood-biomaterial interactions that are fueling a renaissance in the field of material hemocompatibility. It will be useful for clinicians, scientists, engineers, representatives of industry and regulatory bodies working on the problem of developing hemocompatible materials and devices for treating cardiovascular disorders.
(Copyright © 2019 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved.)
Databáze: MEDLINE
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