Multiple melanocytic nevi restricted to mycosis fungoides patches in pediatric and young-adult patients. The potential role of local immunosuppression.

Autor: Martinez-Escala ME; Department of Dermatology, Northwestern University, Feinberg School of Medicine, Chicago, Illinois., Amin SM; Department of Dermatology, Northwestern University, Feinberg School of Medicine, Chicago, Illinois., Sable KA; Department of Dermatology, Northwestern University, Feinberg School of Medicine, Chicago, Illinois., Gerami P; Department of Dermatology, Northwestern University, Feinberg School of Medicine, Chicago, Illinois., Guitart J; Department of Dermatology, Northwestern University, Feinberg School of Medicine, Chicago, Illinois.
Jazyk: angličtina
Zdroj: Pediatric dermatology [Pediatr Dermatol] 2019 Mar; Vol. 36 (2), pp. 232-235. Date of Electronic Publication: 2019 Jan 18.
DOI: 10.1111/pde.13738
Abstrakt: We described the development of multiple melanocytic nevi within long-standing MF patches in four young patients. Mycosis fungoides (MF) patches are characterized by a regulatory-like cytokine profile leading to local immune suppression. The proliferation of nevomelanocytes is regulated by cellular senescence mechanisms mediated by immune system. The immunosuppressive effect of MF infiltrate in conjunction with the systemic effect of treatments may play a specific role in the nevomelanogenesis of the patients herein described.
(© 2019 Wiley Periodicals, Inc.)
Databáze: MEDLINE
Externí odkaz: