Design, Synthesis, and Biological Evaluation of 6-Benzoxazole Benzimidazole Derivatives with Antihypertension Activities.

Autor: Wu Z; Department of Pharmaceutical Science and Technology, College of Chemistry and Biology, Donghua University, Shanghai 201620, China., Bao XL; Department of Pharmaceutical Science and Technology, College of Chemistry and Biology, Donghua University, Shanghai 201620, China., Zhu WB; Department of Pharmaceutical Science and Technology, College of Chemistry and Biology, Donghua University, Shanghai 201620, China., Wang YH; Department of Pharmaceutical Science and Technology, College of Chemistry and Biology, Donghua University, Shanghai 201620, China., Phuong Anh NT; Department of Pharmaceutical Science and Technology, College of Chemistry and Biology, Donghua University, Shanghai 201620, China., Wu XF; Shanghai Xianhui Pharmaceutical Co., Ltd., Shanghai 200433, China., Yan YJ; Shanghai Xianhui Pharmaceutical Co., Ltd., Shanghai 200433, China., Chen ZL; Department of Pharmaceutical Science and Technology, College of Chemistry and Biology, Donghua University, Shanghai 201620, China.
Jazyk: angličtina
Zdroj: ACS medicinal chemistry letters [ACS Med Chem Lett] 2018 Dec 31; Vol. 10 (1), pp. 40-43. Date of Electronic Publication: 2018 Dec 31 (Print Publication: 2019).
DOI: 10.1021/acsmedchemlett.8b00335
Abstrakt: A series of new angiotensin II receptor 1 antagonists were prepared. They displayed nanomolar affinity to AT 1 receptor and could decrease blood pressure efficiently in spontaneously hypertensive rats. Among them, compounds 1b and 2b could reduce the blood pressure with more or equal potency compared to Losartan. So, compounds 1b and 2b could be considered as potential antihypertension drug candidates.
Competing Interests: The authors declare no competing financial interest.
Databáze: MEDLINE
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