| Autor: |
Belem da Silva CT; 1 School of Medicine Universidade do Vale do Rio dos Sinos São Leopoldo Rio Grande do Sul Brazil., Hoffmann MS; 2 Universidade Federal de Santa Maria Santa Maria Rio Grande do Sul Brazil., Sant Anna RT; 3 Instituto de Cardiologia Fundação Universitária de Cardiologia Clinical Research Center Porto Alegre Rio Grande do Sul Brazil., Wehrmeister FC; 4 Postgraduate Program in Epidemiology Federal University of Pelotas Rio Grande do Sul Brazil., Gonçalves H; 4 Postgraduate Program in Epidemiology Federal University of Pelotas Rio Grande do Sul Brazil., Oliveira IO; 5 Department of Physiology and Pharmacology Federal University of Pelotas Capão do Leão Rio Grande do Sul Brazil., Oliveira PD; 4 Postgraduate Program in Epidemiology Federal University of Pelotas Rio Grande do Sul Brazil., Vargas da Silva AM; 6 Graduate Program in Functional Rehabilitation Federal University of Santa Maria Rio Grande do Sul Brazil., Kieling C; 7 Graduate Program in Psychiatry and Behavioral Sciences Federal University of Rio Grande do Sul Porto Alegre Rio Grande do Sul Brazil., Manfro GG; 7 Graduate Program in Psychiatry and Behavioral Sciences Federal University of Rio Grande do Sul Porto Alegre Rio Grande do Sul Brazil., Menezes AMB; 4 Postgraduate Program in Epidemiology Federal University of Pelotas Rio Grande do Sul Brazil. |
| Jazyk: |
angličtina |
| Zdroj: |
Journal of the American Heart Association [J Am Heart Assoc] 2019 Jan 22; Vol. 8 (2), pp. e011011. |
| DOI: |
10.1161/JAHA.118.011011 |
| Abstrakt: |
Background Emotional disorders are risk factors for atherosclerosis and consequent cardiovascular disease. However, it is not clear whether emotional symptoms (ESs) have direct effects on cardiovascular disease. The aim of the present study is to investigate the effects of early ESs on carotid atherosclerosis in young adults. Methods and Results We tested the association between expression of ESs at 11 and 15 years of age and carotid intima-media thickness at 18 years of age in the 1993 Pelotas Birth Cohort (N=5249, n=4336 with complete mental health data). ES s were assessed using the Strengths and Difficulties Questionnaire. Propensity score weighting procedure was run using generalized boosted regression model to adjust for potential confounding between exposure and outcome. We also tested whether traditional cardiovascular risk factors could mediate this relationship. Adjusted high expression of ESs , both at 11 and 15 years of age, led to mean increases in carotid intima-media thickness of 1.84 and 2.58 μm, respectively, at 18 years of age (both P<0.001). Longitudinal effects of ESs on atherosclerosis were direct and not significantly mediated by traditional cardiovascular risk factors. Male sex at age 15 years significantly enhanced the effects of ESs on carotid intima-media thickness at age 18 years ( P<0.001 for interaction): although high expression of ESs led to mean increases of 1.14 μm in females ( P<0.05), it led to mean increases of 5.83 μm in males ( P<0.001). Conclusions In this large birth cohort, expression of ESs in adolescence was longitudinally associated with a higher carotid intima-media thickness in young adults. The association is direct and not mediated by traditional cardiovascular risk factors. Interactions by sex might have important implications for designing future interventions. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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