| Autor: |
Andreiana BC; PhD student, Department of Morphopathology, University of Medicine and Pharmacy of Craiova., Stepan AE; Department of Morphopathology, University of Medicine and Pharmacy of Craiova., Mărgăritescu C; Department of Morphopathology, University of Medicine and Pharmacy of Craiova., Al Khatib AM; PhD student, Department of Morphopathology, University of Medicine and Pharmacy of Craiova., Florescu MM; Department of Morphopathology, University of Medicine and Pharmacy of Craiova., Ciurea RN; Department of Morphopathology, University of Medicine and Pharmacy of Craiova., Simionescu CE; Department of Morphopathology, University of Medicine and Pharmacy of Craiova. |
| Jazyk: |
angličtina |
| Zdroj: |
Current health sciences journal [Curr Health Sci J] 2018 Jul-Sep; Vol. 44 (3), pp. 201-205. Date of Electronic Publication: 2018 Jul 15. |
| DOI: |
10.12865/CHSJ.44.03.01 |
| Abstrakt: |
Clear cell renal cell carcinoma (CCRCC) are the most frequent type of renal cell carcinoma. Fuhrman grade and tumor stage are prognostic factors with great importance in survival rate. This study was performed on 75 cases of CCRCC diagnosed by the Anatomical Pathology Laboratory of the County Clinical Emergency Hospital of Craiova between 2014 and 2017. The biological material was represented by pieces of nephrectomy. The cases were analyzed on two criteria: epidemiology (age, sex) and histopathology (Fuhrman grade, tumor stage, architectural pattern, sarcomatoid transformation, and necrosis). Statistical analysis was done using Chi Square tests in IBM SPSS software. Average diagnosis age of CCRCC was 58.8±10.2 years, predominantly in male patients (66.7%). Tumor sizes were between 2 and 14cm, with an average of 6.7±2.9cm. Most cases were determined to be tumor stage III (60%) and Fuhrman grade 2 (56%), followed, in order of frequency, by tumor stages I and II (28% and 10.7%) and Fuhrman grades 3 and 1 (21.3% and 20%). High Fuhrman grade CCRCC were significantly associated with advanced tumor stage (p<0.05, χ 2 test). Most cases presented a mixed pattern, significantly associated with advanced tumor stages (p<0.05, χ 2 test). Even though the presence of sarcomatoid transformation was more frequent in advanced tumor stages, it wasn't significantly linked to them (p<0.05, χ 2 test). Conclusions: Analyzed histopathological parameters are useful for determining CCRCC aggressiveness. CCRCC in advanced tumor stages is associated with high Fuhrman grade and mixed architectural pattern. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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