Male-Specific Conditioned Pain Hypersensitivity in Mice and Humans.

Autor:	Martin LJ; Department of Psychology and Alan Edwards Centre for Research on Pain, McGill University, Montreal, QC H3A 1B1, Canada; Department of Psychology, University of Toronto, Mississauga, Mississauga, ON L5L 1C6, Canada., Acland EL; Department of Psychology and Alan Edwards Centre for Research on Pain, McGill University, Montreal, QC H3A 1B1, Canada; Department of Psychology, University of Toronto, Mississauga, Mississauga, ON L5L 1C6, Canada., Cho C; Department of Psychology, University of Toronto, Mississauga, Mississauga, ON L5L 1C6, Canada., Gandhi W; Faculty of Dentistry and Alan Edwards Centre for Research on Pain, McGill University, Montreal, QC H3A 1G1, Canada., Chen D; Department of Psychology and Alan Edwards Centre for Research on Pain, McGill University, Montreal, QC H3A 1B1, Canada., Corley E; Department of Psychology and Alan Edwards Centre for Research on Pain, McGill University, Montreal, QC H3A 1B1, Canada., Kadoura B; Department of Psychology and Alan Edwards Centre for Research on Pain, McGill University, Montreal, QC H3A 1B1, Canada., Levy T; Department of Psychology and Alan Edwards Centre for Research on Pain, McGill University, Montreal, QC H3A 1B1, Canada., Mirali S; Department of Psychology and Alan Edwards Centre for Research on Pain, McGill University, Montreal, QC H3A 1B1, Canada., Tohyama S; Department of Psychology, University of Toronto, Mississauga, Mississauga, ON L5L 1C6, Canada., Khan S; Department of Psychology, University of Toronto, Mississauga, Mississauga, ON L5L 1C6, Canada., MacIntyre LC; Department of Psychology and Alan Edwards Centre for Research on Pain, McGill University, Montreal, QC H3A 1B1, Canada., Carlson EN; Department of Psychology, University of Toronto, Mississauga, Mississauga, ON L5L 1C6, Canada., Schweinhardt P; Faculty of Dentistry and Alan Edwards Centre for Research on Pain, McGill University, Montreal, QC H3A 1G1, Canada; Balgrist University Hospital, University of Zurich, 8005 Zurich, Switzerland., Mogil JS; Department of Psychology and Alan Edwards Centre for Research on Pain, McGill University, Montreal, QC H3A 1B1, Canada; Department of Anesthesia, McGill University, Montreal, QC H3G 1Y6, Canada. Electronic address: jeffrey.mogil@mcgill.ca.
Jazyk:	angličtina
Zdroj:	Current biology : CB [Curr Biol] 2019 Jan 21; Vol. 29 (2), pp. 192-201.e4. Date of Electronic Publication: 2019 Jan 10.
DOI:	10.1016/j.cub.2018.11.030
Abstrakt:	Pain memories are hypothesized to be critically involved in the transition of pain from an acute to a chronic state. To help elucidate the underlying neurobiological mechanisms of pain memory, we developed novel paradigms to study context-dependent pain hypersensitivity in mouse and human subjects, respectively. We find that both mice and people become hypersensitive to acute, thermal nociception when tested in an environment previously associated with an aversive tonic pain experience. This sensitization persisted for at least 24 hr and was only present in males of both species. In mice, context-dependent pain hypersensitivity was abolished by castrating male mice, pharmacological blockade of the hypothalamic-pituitary-adrenal axis, or intracerebral or intrathecal injections of zeta inhibitory peptide (ZIP) known to block atypical protein kinase C (including the protein kinase Mζ isoform). In humans, men, but not women, self-reported higher levels of stress when tested in a room previously associated with tonic pain. These models provide a new, completely translatable means for studying the relationship between memory, pain, and stress. (Copyright © 2018 Elsevier Ltd. All rights reserved.)
Databáze:	MEDLINE
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