The role of dietary non-heme iron load and peripheral nerve inflammation in the development of peripheral neuropathy (PN) in obese non-diabetic leptin-deficient ob/ob mice.

Autor:	Kosacka J; a Department of Neurology , University of Leipzig , Leipzig , Germany., Woidt K; b Institute of Anatomy , University of Leipzig , Leipzig , Germany., Toyka KV; c Department of Neurology , University of Würzburg , Würzburg , Germany., Paeschke S; b Institute of Anatomy , University of Leipzig , Leipzig , Germany., Klöting N; d Department of Medicine , University of Leipzig , Leipzig , Germany.; e Integrated Research and Treatment Center (IFB) Adiposity Disease , Leipzig , Germany., Bechmann I; b Institute of Anatomy , University of Leipzig , Leipzig , Germany., Blüher M; d Department of Medicine , University of Leipzig , Leipzig , Germany., Thiery J; f Institute of Laboratory Medicine, Clinical Chemistry and Molecular Diagnostics (ILM) , University of Leipzig , Leipzig , German., Ossmann S; g Heart Center , University of Leipzig , Leipzig , Germany., Baum P; a Department of Neurology , University of Leipzig , Leipzig , Germany., Nowicki M; b Institute of Anatomy , University of Leipzig , Leipzig , Germany.
Jazyk:	angličtina
Zdroj:	Neurological research [Neurol Res] 2019 Apr; Vol. 41 (4), pp. 341-353. Date of Electronic Publication: 2019 Jan 13.
DOI:	10.1080/01616412.2018.1564191
Abstrakt:	Introduction: Here, we investigated inflammatory signs of peripheral nerves in leptin-deficient obese ob/ob mice and the modulating effects of the exogenous iron load. Methods: Ob/ob and ob/+ control mice were fed with high, standard, or low iron diet for four months. Results: We found intraepidermal nerve fiber degeneration in foot skin and low-grade neuropathic abnormalities including mildly slowed motor and compound sensory nerve conduction velocities and low-grade macrophage and T-cell infiltration without overt neuropathology in sciatic nerves of all ob/ob mice. Low dietary iron load caused more pronounced abnormalities than high iron load in ob/ob mice. Discussion: Our data suggest that dietary non-heme iron deficiency may be a modulating factor in the pathogenesis of peripheral neuropathy in obese ob/ob mice with metabolic syndrome. Once the mechanisms can be further elucidated, how low dietary iron augments peripheral nerve degeneration and dysfunction via pro-inflammatory pathways and new therapeutic strategies could be developed. Abbreviations: CMAP: compound muscle action potential; cSNCV: compound sensory nerve conduction velocity; IENFD: intraepidermal nerve fiber density; LDL: low-density lipoprotein; MetS: metabolic syndrome; MNCV: motor conduction velocity; NCV: nerve conduction velocity; PN: peripheral neuropathy; PNS: peripheral nervous system; STZ: streptozotocin; T2D: type 2 diabetes mellitus; TNF alpha: tumor necrosis factor alpha; WHO: World Health Organization.
Databáze:	MEDLINE
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