Sensorineural Impairments, Cardiovascular Risk Factors, and 10-Year Incidence of Cognitive Impairment and Decline in Midlife: The Beaver Dam Offspring Study.

Autor:	Schubert CR; Department of Ophthalmology and Visual Sciences, School of Medicine and Public Health, University of Wisconsin-Madison., Cruickshanks KJ; Department of Ophthalmology and Visual Sciences, School of Medicine and Public Health, University of Wisconsin-Madison.; Department of Population Health Sciences, School of Medicine and Public Health, University of Wisconsin-Madison, Hsinchu, Taiwan., Fischer ME; Department of Ophthalmology and Visual Sciences, School of Medicine and Public Health, University of Wisconsin-Madison., Pinto AA; Department of Ophthalmology and Visual Sciences, School of Medicine and Public Health, University of Wisconsin-Madison., Chen Y; Department of Ophthalmology and Visual Sciences, School of Medicine and Public Health, University of Wisconsin-Madison., Huang GH; Institute of Statistics, National Chiao Tung University, Hsinchu, Taiwan., Klein BEK; Department of Ophthalmology and Visual Sciences, School of Medicine and Public Health, University of Wisconsin-Madison., Klein R; Department of Ophthalmology and Visual Sciences, School of Medicine and Public Health, University of Wisconsin-Madison., Pankow JS; Division of Epidemiology and Community Health, School of Public Health, University of Minnesota, Minneapolis., Paulsen AJ; Department of Ophthalmology and Visual Sciences, School of Medicine and Public Health, University of Wisconsin-Madison., Dalton DS; Department of Ophthalmology and Visual Sciences, School of Medicine and Public Health, University of Wisconsin-Madison., Tweed TS; Department of Ophthalmology and Visual Sciences, School of Medicine and Public Health, University of Wisconsin-Madison.
Jazyk:	angličtina
Zdroj:	The journals of gerontology. Series A, Biological sciences and medical sciences [J Gerontol A Biol Sci Med Sci] 2019 Oct 04; Vol. 74 (11), pp. 1786-1792.
DOI:	10.1093/gerona/glz011
Abstrakt:	Background: Sensorineural impairments and cardiovascular risk factors (CVRF) and disease (CVD) in midlife may be important predictors of future cognitive health, but longitudinal studies that include multiple sensorineural measures in middle-aged adults are lacking. Methods: Hearing, vision, and olfaction, and CVRF and CVD were measured at the Beaver Dam Offspring Study baseline (2005-2008) examination. The Mini-Mental State Examination and Trail Making Tests A and B were administered at all phases and additional cognitive function measures were obtained at 5 (2010-2013) and 10 years (2015-2017). Cox proportional hazards models were used to evaluate associations between baseline sensorineural impairments, CVRF, CVD, and 10-year cumulative incidence of cognitive impairment and decline. Results: There were 2,556 participants (22-84 years) without cognitive impairment at baseline and data from at least one follow-up. In a multivariable model including age, sex, education, and head injury, visual impairment (hazard ratio = 2.59, 95% confidence interval = 1.34, 5.02), olfactory impairment (hazard ratio = 3.18, 95% confidence interval = 1.53, 6.59), CVD (hazard ratio = 2.37, 95% confidence interval = 1.24, 4.52), and not consuming alcohol in the past year (hazard ratio = 2.21, 95% confidence interval = 1.16, 4.19) were associated with the 10-year cumulative incidence of cognitive impairment. Current smoking and diabetes were associated with increased risk, and exercise with decreased risk, of 10-year decline in cognitive function. Conclusions: Visual and olfactory impairments, CVRF, and CVD were associated with the 10-year cumulative incidence of cognitive impairment and decline in middle-aged adults. Identifying modifiable factors associated with cognitive decline and impairment in midlife may provide opportunities for prevention or treatment and improve cognitive health later in life. (© The Author(s) 2019. Published by Oxford University Press on behalf of The Gerontological Society of America. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.)
Databáze:	MEDLINE
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