| Autor: |
Wisniewski PJ; Department of Kinesiology and Health and The Rutgers Center for Lipid Research and The Center for Digestive Health, New Jersey Institute for Food, Nutrition and Health, Rutgers University, New Brunswick, NJ 08901, USA. paulw@kines.rutgers.edu., Dowden RA; Department of Kinesiology and Health and The Rutgers Center for Lipid Research and The Center for Digestive Health, New Jersey Institute for Food, Nutrition and Health, Rutgers University, New Brunswick, NJ 08901, USA. rad267@rutgers.edu., Campbell SC; Department of Kinesiology and Health and The Rutgers Center for Lipid Research and The Center for Digestive Health, New Jersey Institute for Food, Nutrition and Health, Rutgers University, New Brunswick, NJ 08901, USA. saracamp@kines.rutgers.edu. |
| Abstrakt: |
Inflammation and its resolution is a tenuous balance that is under constant contest. Though several regulatory mechanisms are employed to maintain homeostasis, disruptions in the regulation of inflammation can lead to detrimental effects for the host. Of note, the gut and microbial dysbiosis are implicated in the pathology of systemic chronic low-grade inflammation which has been linked to several metabolic diseases. What remains to be described is the extent to which dietary fat and concomitant changes in the gut microbiota contribute to, or arise from, the onset of metabolic disorders. The present review will highlight the role of microorganisms in host energy regulation and several mechanisms that contribute to inflammatory pathways. This review will also discuss the immunomodulatory effects of the endocannabinoid system and its link with the gut microbiota. Finally, a brief discussion arguing for improved taxonomic resolution (at the species and strain level) is needed to deepen our current knowledge of the microbiota and host inflammatory state. |
