Resolution of Inflammation Through the Lipoxin and ALX/FPR2 Receptor Pathway Protects Against Abdominal Aortic Aneurysms.

Autor: Petri MH; Department of Medicine, Karolinska Institutet, Stockholm, Sweden., Thul S; Department of Medicine, Karolinska Institutet, Stockholm, Sweden., Andonova T; Department of Medicine, Karolinska Institutet, Stockholm, Sweden., Lindquist-Liljeqvist M; Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden., Jin H; Department of Medicine, Karolinska Institutet, Stockholm, Sweden., Skenteris NT; Department of Medicine, Karolinska Institutet, Stockholm, Sweden., Arnardottir H; Department of Medicine, Karolinska Institutet, Stockholm, Sweden., Maegdefessel L; Department of Medicine, Karolinska Institutet, Stockholm, Sweden., Caidahl K; Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden.; Department of Molecular and Clinical Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden., Perretti M; William Harvey Research Institute, Barts and London School of Medicine, Centre for Inflammation and Therapeutic Innovation, Queen Mary University of London, London, United Kingdom., Roy J; Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden.; Theme Heart and Vessels, Division of Valvular and Coronary Disease, Karolinska University Hospital, Stockholm, Sweden., Bäck M; Department of Medicine, Karolinska Institutet, Stockholm, Sweden.; Theme Heart and Vessels, Division of Valvular and Coronary Disease, Karolinska University Hospital, Stockholm, Sweden.
Jazyk: angličtina
Zdroj: JACC. Basic to translational science [JACC Basic Transl Sci] 2018 Dec 31; Vol. 3 (6), pp. 719-727. Date of Electronic Publication: 2018 Dec 31 (Print Publication: 2018).
DOI: 10.1016/j.jacbts.2018.08.005
Abstrakt: An abdominal aortic aneurysm (AAA) is a progressive aortic dilation that may lead to rupture, which is usually lethal. This study identifies the state of failure in the resolution of inflammation by means of decreased expression of the pro-resolving receptor A lipoxin/formyl peptide receptor 2 (ALX/FPR2) in the adventitia of human AAA lesions. Mimicking this condition by genetic deletion of the murine ALX/FPR2 ortholog in hyperlipidemic mice exacerbated the aortic dilation induced by angiotensin II infusion, associated with decreased vascular collagen and increased inflammation. The authors also identified key roles of lipoxin formation through 12/15-lipoxygenase and neutrophil p38 mitogen-activated protein kinase. In conclusion, this study established pro-resolving signaling by means of the ALX/FPR2 receptor in aneurysms and vascular inflammation.
Databáze: MEDLINE
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