Omega-3 Supplementation Improves Pruritus in Continuous Ambulatory Peritoneal Dialysis Patients: A Crossover Randomized Pilot Clinical Trial.

Autor:	Lahiji AP; Department of Preventive Medicine and Community Health, University of Texas Medical Branch, USA., Mortazavi M; Department of Internal Medicine, Isfahan University of Medical Sciences, Isfahan, Iran.; Isfahan Kidney Diseases Research Center, Al-Zahra Research Institute, Isfahan University of Medical Sciences, Isfahan, Iran., Tirani SA; Department of Internal Medicine, Isfahan University of Medical Sciences, Isfahan, Iran., Moeinzadeh F; Department of Internal Medicine, Isfahan University of Medical Sciences, Isfahan, Iran.; Isfahan Kidney Diseases Research Center, Al-Zahra Research Institute, Isfahan University of Medical Sciences, Isfahan, Iran., Bidaki EZ; Department of Internal Medicine, Isfahan University of Medical Sciences, Isfahan, Iran., Naini AE; Department of Internal Medicine, Isfahan University of Medical Sciences, Isfahan, Iran.; Isfahan Kidney Diseases Research Center, Al-Zahra Research Institute, Isfahan University of Medical Sciences, Isfahan, Iran., Faghihi G; Department of Dermatology, Isfahan University of Medical Sciences, Isfahan, Iran., Toghyani A; Department of Internal Medicine, Isfahan University of Medical Sciences, Isfahan, Iran., Farajzadegan Z; Department of Community and Family Medicine, Isfahan University of Medical Sciences, Isfahan, Iran.
Jazyk:	angličtina
Zdroj:	Journal of research in pharmacy practice [J Res Pharm Pract] 2018 Oct-Dec; Vol. 7 (4), pp. 195-199.
DOI:	10.4103/jrpp.JRPP_18_64
Abstrakt:	Objective: Pruritus is a prevalent skin condition in end-stage renal disease patients. Omega-3 fatty acids have been shown to reduce pruritus in hemodialysis patients. Our objective was to assess the effect of 3 g/day omega-3 supplementation on pruritus among continuous ambulatory peritoneal dialysis (CAPD) patients. Methods: In this two-period, two-sequence crossover randomized clinical trial, 40 eligible subjects (CAPD patients who complained of pruritus for more than 8 weeks) were randomized to 3 g of omega-3 ( n = 20) or identical placebo capsules ( n = 20) for 4 weeks. After a wash-out period of 6 weeks, patients were crossed over to the alternate treatment option. Pruritus intensity was assessed using the visual analog scale (VAS) at baseline, 2-and 4-weeks post-intervention in each study period. Both patients and investigators were blinded to the study protocol. Findings: No significant carry-over effect was detected. The mean pruritus score (VAS) in the omega-3 group compared with placebo group after the first (-3.02 vs. -0.48, P < 0.001) and second (-4.09 vs. -0.43, P < 0.001) intervention periods showed higher significant decrease. Conclusion: In summary, omega-3 supplementation is an effective treatment for pruritus alleviation in CAPD patients. Further studies are needed to determine the mechanisms underlying antipruritic effects of omega-3. Competing Interests: There are no conflicts of interest.
Databáze:	MEDLINE
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