Maximum tolerated doses and erythropoiesis effects in the mouse bone marrow by 79 pesticides' technical materials assessed with the micronucleus assay.

Autor: Ilyushina N; The Federal Budgetary Establishment of Science 'Federal Scientific Center of Hygiene named after F. F. Erisman' of the Federal Service for Surveillance on Consumer Rights Protection and Human Wellbeing, 2 Semashko street, Mytishchi, Moscow Oblast', 141014, Russian Federation., Goumenou M; Center of Toxicology Science & Research, Medical School, University of Crete, Heraklion, Crete, Greece., Stivaktakis PD; Laboratory of Toxicology, Medical School, University of Crete, Voutes, 71409 Heraklion, Crete, Greece., Vardavas AI; Laboratory of Toxicology, Medical School, University of Crete, Voutes, 71409 Heraklion, Crete, Greece., Masaltsev G; The Federal Budgetary Establishment of Science 'Federal Scientific Center of Hygiene named after F. F. Erisman' of the Federal Service for Surveillance on Consumer Rights Protection and Human Wellbeing, 2 Semashko street, Mytishchi, Moscow Oblast', 141014, Russian Federation., Averianova N; The Federal Budgetary Establishment of Science 'Federal Scientific Center of Hygiene named after F. F. Erisman' of the Federal Service for Surveillance on Consumer Rights Protection and Human Wellbeing, 2 Semashko street, Mytishchi, Moscow Oblast', 141014, Russian Federation., Dmitricheva O; The Federal Budgetary Establishment of Science 'Federal Scientific Center of Hygiene named after F. F. Erisman' of the Federal Service for Surveillance on Consumer Rights Protection and Human Wellbeing, 2 Semashko street, Mytishchi, Moscow Oblast', 141014, Russian Federation., Revazova Y; The Federal Budgetary Establishment of Science 'Federal Scientific Center of Hygiene named after F. F. Erisman' of the Federal Service for Surveillance on Consumer Rights Protection and Human Wellbeing, 2 Semashko street, Mytishchi, Moscow Oblast', 141014, Russian Federation., Tsatsakis AM; Laboratory of Toxicology, Medical School, University of Crete, Voutes, 71409 Heraklion, Crete, Greece., Rakitskii V; The Federal Budgetary Establishment of Science 'Federal Scientific Center of Hygiene named after F. F. Erisman' of the Federal Service for Surveillance on Consumer Rights Protection and Human Wellbeing, 2 Semashko street, Mytishchi, Moscow Oblast', 141014, Russian Federation.
Jazyk: angličtina
Zdroj: Toxicology reports [Toxicol Rep] 2018 Dec 22; Vol. 6, pp. 105-110. Date of Electronic Publication: 2018 Dec 22 (Print Publication: 2019).
DOI: 10.1016/j.toxrep.2018.12.006
Abstrakt: Effects of technical materials of pesticide active ingredients, belonging to various chemical classes, on erythropoiesis in mouse bone marrow were studied as part of the research on the pesticide mutagenic activity in micronucleus test. The purpose of the present study was to estimate the toxic action of the test substances on the target organ and the validity of the results of the micronucleus assay under conditions of erythropoiesis suppression. It was demonstrated that intragastrically administrated triazole pesticides reached bone marrow (target organ where micronucleus induction was assessed) and exerted an inhibitory effect on erythropoiesis. The effects of triazole pesticides were enhanced in the following order: difenoconazole ≤ tebuconazole < cyproconazole < flutriafol. Furthermore, an association between structural features of molecules and specific target organ activity of the test pesticides was observed. Based on the data on the general toxicity and the results of the evaluation of the effects on erythropoiesis, the maximum tolerated doses (MTDs) of 79 different technical materials of pesticides for CD-1 mice were determined.
Databáze: MEDLINE