| Autor: |
Tranquillo E; Department of Engineering, University of Campania 'Luigi Vanvitelli', via Roma 29, 81031 Aversa, Italy. elisabetta.tranquillo@unicampania.it., Barrino F; Department of Engineering, University of Campania 'Luigi Vanvitelli', via Roma 29, 81031 Aversa, Italy. federicobarrino92@hotmail.it., Dal Poggetto G; Ecoricerche srl, via Principi Normanni 36, 81043 Capua Caserta, Italy. giogiodp@hotmail.it., Blanco I; Department of Civil Engineering and Architecture and UdR-Catania Consorzio INSTM, University of Catania, Viale Andrea Doria 6, 95125 Catania, Italy. iblanco@unict.it. |
| Jazyk: |
angličtina |
| Zdroj: |
Materials (Basel, Switzerland) [Materials (Basel)] 2019 Jan 06; Vol. 12 (1). Date of Electronic Publication: 2019 Jan 06. |
| DOI: |
10.3390/ma12010155 |
| Abstrakt: |
Implanted biomedical devices can induce adverse responses in the human body, which can cause failure of the implant-referred to as implant failure. Early implant failure is induced numerous factors, most importantly, infection and inflammation. Natural products are, today, one of the main sources of new drug molecules due to the development of pathogenic bacterial strains that possess resistance to more antibiotics used currently in various diseases. The aim of this work is the sol⁻gel synthesis of antibacterial biomedical implants. In the silica matrix, different percentages (6, 12, 24, 50 wt %) of polyethylene glycol (PEG) or poly(ε-caprolactone) (PCL) were embedded. Subsequently, the ethanol solutions with high amounts of chlorogenic acid (CGA 20 wt %) were slowly added to SiO₂/PEG and SiO₂/PCL sol. The interactions among different organic and inorganic phases in the hybrid materials was studied by Fourier transform infrared (FTIR) spectroscopy. Furthermore, the materials were soaked in simulated body fluid (SBF) for 21 days and the formation of a hydroxyapatite layer on their surface was evaluated by FTIR and XRD analysis. Finally, Escherichia coli and Pseudomonas aeruginosa were incubated with several hybrids, and the diameter of zone of inhibition was observed to assessment the potential antibacterial properties of the hybrids. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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