| Autor: |
Morais JBS; Department of Nutrition, Health Sciences Center, Federal University of Piauí, Teresina, Piauí, Brazil., Severo JS; Department of Nutrition, Health Sciences Center, Federal University of Piauí, Teresina, Piauí, Brazil., Beserra JB; Department of Nutrition, Health Sciences Center, Federal University of Piauí, Teresina, Piauí, Brazil., de Oiveira ARS; Department of Nutrition, Health Sciences Center, Federal University of Piauí, Teresina, Piauí, Brazil., Cruz KJC; Department of Nutrition, Health Sciences Center, Federal University of Piauí, Teresina, Piauí, Brazil., de Sousa Melo SR; Department of Nutrition, Health Sciences Center, Federal University of Piauí, Teresina, Piauí, Brazil., do Nascimento GVR; State University of Piauí, Teresina, Piauí, Brazil., de Macedo GFS; Hopital Gastrovita, Teresina, Piauí, Brazil., do Nascimento Marreiro D; Department of Nutrition, Health Sciences Center, Federal University of Piauí, Teresina, Piauí, Brazil. dilina.marreiro@gmail.com. |
| Abstrakt: |
Adipose tissue is considered an endocrine organ and its excess compromises the immune response and the metabolism of hormones and nutrients. Furthermore, visceral fat accumulation contributes to increased cortisol synthesis, which in turn induces metallothionein and Zip14 expression, which are proteins that contribute to reducing plasma zinc levels. Zinc plays a critical role in the secretion and signaling of insulin. Changes in the biochemical parameters of zinc, as observed in individuals who are obese, contribute to the manifestation of related disorders such as insulin resistance. Thus, the purpose of this review is to provide an update on the current information on the relationship between cortisol, zinc, and insulin resistance in obesity. The data in the literature provide evidence that cortisol affects zinc metabolism, and indicate possible repercussions on insulin signaling that might contribute to the development of resistance to the actions of insulin in obesity. |
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