Six-month clinical outcomes of non-surgical periodontal treatment with antibiotics on apoptosis markers in aggressive periodontitis.

Autor: Aral K; Division of Periodontics, Malatya Oral and Dental Heath Hospital, Malatya, Turkey., Aral CA; Department of Periodontology, Faculty of Dentistry, Inonu University, Malatya, Turkey., Kapila Y; Department of Orofacial Sciences, School of Dentistry, University of California, California.
Jazyk: angličtina
Zdroj: Oral diseases [Oral Dis] 2019 Apr; Vol. 25 (3), pp. 839-847. Date of Electronic Publication: 2019 Jan 30.
DOI: 10.1111/odi.13032
Abstrakt: Objective: Extrinsic and intrinsic pathways of apoptosis are involved in generalized aggressive periodontitis (GAgP). The aim of this study was to evaluate 6-month clinical outcomes relative to apoptosis of one-stage full-mouth disinfection (OSFMD) and systemic antibiotics (SA) in the treatment of GAgP.
Methods: Twenty-six patients with GAgP were included in this prospective follow-up intervention study. Gingival crevicular fluid (GCF) was collected from patients at baseline and 3 and 6 months after periodontal therapy, which consisted of OSFMD and SA (amoxicillin and metronidazole, 500 mg each for 7 days). The levels of p53, caspase-3, TNF-α, TRAIL, IL-1β, and IL-10 in GCF were measured via ELISA.
Results: Periodontal parameters were improved at 3 and 6 months compared to baseline (p < 0.05). p53 was decreased up to 6 months (p < 0.05). TRAIL, TNF-α, and IL-10 were similar at baseline and 3 and 6 months. Caspase-3 and IL-1β were decreased at 3 months (p < 0.05), but similar at 6 months compared to baseline (p > 0.05).
Conclusion: Although OSFMD plus SA improves clinical periodontal parameters up to 6 months, this treatment protocol differentially regulates the apoptosis markers caspase-3 at 3 months and p53 at 6 months without influencing TRAIL in GCF.
(© 2019 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd. All rights reserved.)
Databáze: MEDLINE
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