Effect of methadone and acepromazine premedication on tear production in dogs.

Autor: Volk HA; Melbourne EyeVet, Mulgrave, VIC, Australia., West E; Anaesthesia Department, Davies Veterinary Specialists, Hertfordshire, UK., Linn-Pearl RN; Eye Veterinary Clinic, Herefordshire, UK., Fricker GV; Ophthalmology Department, Davies Veterinary Specialists, Hertfordshire, UK., Panti A; Anaesthesia Department, Royal Dick School of Veterinary Studies, University of Edinburgh, Edinburgh, UK., Gould DJ; Ophthalmology Department, Davies Veterinary Specialists, Hertfordshire, UK.
Jazyk: angličtina
Zdroj: Veterinary record open [Vet Rec Open] 2018 Dec 05; Vol. 5 (1), pp. e000298. Date of Electronic Publication: 2018 Dec 05 (Print Publication: 2018).
DOI: 10.1136/vetreco-2018-000298
Abstrakt: Objectives: To evaluate the combined effect of intramuscular acepromazine and methadone on tear production in dogs undergoing general anaesthesia for elective, non-ocular procedures.
Design: Prospective, non-randomised, pre-post treatment study.
Setting: Patients were recruited from a referral practice in the UK.
Methods: Thirty client-owned dogs were enrolled in this study and received a combined intramuscular premedication of methadone (0.3 mg/kg) and acepromazine (0.02 mg/kg) before general anaesthesia for elective, non-ocular procedures. Full ophthalmic examination was performed and tear production was quantified using the Schirmer tear test-1 (STT-1). On the day of general anaesthesia, an STT-1 was performed before (STT-1a) and after (STT-1b) intramuscular premedication with methadone/acepromazine.
Results: Using a general linear model, a significant effect on STT-1 results was found for premedication with methadone/acepromazine (P=0.013), but not eye laterality (P=0.527). Following premedication, there was a significant reduction observed in the mean STT-1 readings of left and right eyes between STT-1a (20.4±2.8 mm/min) and STT-1b (16.9±4.1 mm/min; P<0.001). Significantly more dogs had an STT-1 reading less than 15 mm/min in one or both eyes after premedication (30 per cent; 9/30 dogs) compared with before premedication (6.7 per cent; 2/30 dogs; P=0.042).
Conclusions: An intramuscular premedication of methadone and acepromazine results in a decrease in tear production in dogs before elective general anaesthesia. This may contribute to the risk of ocular morbidities, such as corneal ulceration, particularly in patients with lower baseline tear production.
Competing Interests: Competing interests: None declared.
Databáze: MEDLINE
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