The midbrain periaqueductal gray as an integrative and interoceptive neural structure for breathing.

Autor: Faull OK; Translational Neuromodeling Unit, University of Zürich and ETH Zürich, Zürich, Switzerland; Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, UK. Electronic address: faull@biomed.ee.ethz.ch., Subramanian HH; Boston Scientific, Valencia, USA., Ezra M; Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, UK., Pattinson KTS; Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, UK.
Jazyk: angličtina
Zdroj: Neuroscience and biobehavioral reviews [Neurosci Biobehav Rev] 2019 Mar; Vol. 98, pp. 135-144. Date of Electronic Publication: 2019 Jan 03.
DOI: 10.1016/j.neubiorev.2018.12.020
Abstrakt: The periaqueductal gray (PAG) plays a critical role in autonomic function and behavioural responses to threatening stimuli. Recent evidence has revealed the PAG's potential involvement in the perception of breathlessness, a highly threatening respiratory symptom. In this review, we outline the current evidence in animals and humans on the role of the PAG in respiratory control and in the perception of breathlessness. While recent work has unveiled dissociable brain activity within the lateral PAG during perception of breathlessness and ventrolateral PAG during conditioned anticipation in healthy humans, this is yet to be translated into diseases dominated by breathlessness symptomology, such as chronic obstructive pulmonary disease. Understanding how the sub-structures of the PAG differentially interact with interoceptive brain networks involved in the perception of breathlessness will help towards understanding discordant symptomology, and may reveal treatment targets for those debilitated by chronic and pervasive breathlessness.
(Copyright © 2019 The Authors. Published by Elsevier Ltd.. All rights reserved.)
Databáze: MEDLINE
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